Current research on hyaluronic acid-drug bioconjugates
Hyaluronic acid (HA) is a mucopolysaccharide acid composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. Based on numerous characteristics such as viscoelastic properties, water-binding ability, biocompatibility and non-immunogenicity, HA has been approved by FDA f...
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Veröffentlicht in: | European journal of medicinal chemistry 2014-10, Vol.86, p.310-317 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Hyaluronic acid (HA) is a mucopolysaccharide acid composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. Based on numerous characteristics such as viscoelastic properties, water-binding ability, biocompatibility and non-immunogenicity, HA has been approved by FDA for biological and medical applications. In addition, multifarious receptors of HA like CD44, RHAMM and TSG6 are over-expressed on the surface of malignant cells, which play important roles in targeting ability. Bioconjugates linking drugs to HA could improve solubility, prolong half-life, provide active targeting capability and then increase the bioavailability of these coupled drugs by pro-drug strategy. Therefore, a large number of HA-drug bioconjugates have been studied. The purpose of this review was to summarize these HA-drug bioconjugates and further discuss synthetic methods and the relevant application in pharmaceuticals.
Schematic representation of synthesis of HA-drug bioconjugate. [Display omitted]
•This manuscript summarized various synthetic approaches of HA-drug conjugates.•This manuscript summarized the evaluation results of HA-drug conjugates.•The strategy of HA-drug conjugates overcome shortcomings of coupled drugs.•The development of HA-drug conjugates provided a platform for drug delivery. |
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ISSN: | 0223-5234 1768-3254 |
DOI: | 10.1016/j.ejmech.2014.08.067 |