Axonal neuropathy associated with interferon-α treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells
A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biops...
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| Veröffentlicht in: | Acta neuropathologica 1997-11, Vol.94 (5), p.504-508 |
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| container_end_page | 508 |
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| container_title | Acta neuropathologica |
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| creator | QUATTRINI, A COMI, G NEMNI, R MARTINELLI, V VILLA, A CAIMI, M WRABETZ, L CANAL, N |
| description | A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type. |
| doi_str_mv | 10.1007/s004010050740 |
| format | Article |
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The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010050740</identifier><identifier>PMID: 9386785</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Axons - physiology ; Biological and medical sciences ; Biopsy ; Drug toxicity and drugs side effects treatment ; Fluorescent Antibody Technique, Direct ; Hepatitis ; Hepatitis C ; Hepatitis C - complications ; Hepatitis C - drug therapy ; Histocompatibility antigen HLA ; HLA-DR Antigens - metabolism ; Humans ; Immunofluorescence ; Immunohistochemistry ; Immunoreactivity ; Interferon ; Interferon Type I - adverse effects ; Interferon Type I - therapeutic use ; Male ; Medical sciences ; Myelin ; Nerve Fibers, Myelinated - physiology ; Nerve Fibers, Myelinated - ultrastructure ; Neural Conduction - physiology ; Paresthesia ; Peripheral Nervous System Diseases - chemically induced ; Peripheral Nervous System Diseases - pathology ; Peripheral neuropathy ; Pharmacology. Drug treatments ; Recombinant Proteins ; Schwann cells ; Schwann Cells - metabolism ; Sural nerve ; Sural Nerve - pathology ; Sural Nerve - ultrastructure ; Toxicity: nervous system and muscle ; α-Interferon</subject><ispartof>Acta neuropathologica, 1997-11, Vol.94 (5), p.504-508</ispartof><rights>1998 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1997.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-4a93ed4a0817cf43dd988e45ad16378b9babe3b66a67d95c81bd4a33fc112b623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2060962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9386785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>QUATTRINI, A</creatorcontrib><creatorcontrib>COMI, G</creatorcontrib><creatorcontrib>NEMNI, R</creatorcontrib><creatorcontrib>MARTINELLI, V</creatorcontrib><creatorcontrib>VILLA, A</creatorcontrib><creatorcontrib>CAIMI, M</creatorcontrib><creatorcontrib>WRABETZ, L</creatorcontrib><creatorcontrib>CANAL, N</creatorcontrib><title>Axonal neuropathy associated with interferon-α treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.</description><subject>Adult</subject><subject>Axons - physiology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Fluorescent Antibody Technique, Direct</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - drug therapy</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA-DR Antigens - metabolism</subject><subject>Humans</subject><subject>Immunofluorescence</subject><subject>Immunohistochemistry</subject><subject>Immunoreactivity</subject><subject>Interferon</subject><subject>Interferon Type I - adverse effects</subject><subject>Interferon Type I - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myelin</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>Neural Conduction - physiology</subject><subject>Paresthesia</subject><subject>Peripheral Nervous System Diseases - chemically induced</subject><subject>Peripheral Nervous System Diseases - pathology</subject><subject>Peripheral neuropathy</subject><subject>Pharmacology. Drug treatments</subject><subject>Recombinant Proteins</subject><subject>Schwann cells</subject><subject>Schwann Cells - metabolism</subject><subject>Sural nerve</subject><subject>Sural Nerve - pathology</subject><subject>Sural Nerve - ultrastructure</subject><subject>Toxicity: nervous system and muscle</subject><subject>α-Interferon</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0d1q2zAUB3AxVrK02-UuB4KN3rnVt-3dhaxtCoHC1l6bY1kmKraUSXLbPFZfpM80hYbCeiWJ89Mf6RyEvlJyRgkpzyMhguSdJKUgH9CcCs4KIjn_iOaEEFooztgndBzjfT6xUsgZmtW8UmUl5ygtnryDATszBb-FtNlhiNFrC8l0-NGmDbYumdCb4F3x8oxTMJBG4xLufcAbk-_YZCNe4p94tV4Uv35jO46T89npZB9s2uUE_EdvHsE5rM0wxM_oqIchmi-H9QTdXV7cLlfF-ubqerlYF5qXKhUCam46AaSipe4F77q6qoyQ0FHFy6qtW2gNb5UCVXa11BVts-a815SyVjF-gk5fc7fB_51MTM1o4_4F4IyfYkMVU5SLPfz-Dt77KeS-xIYJKhWTsuZZFa9KBx9jMH2zDXaEsGsoafazaP6bRfbfDqlTO5ruTR-an-s_DnWIGoY-gNM2vjFGFKnzL_4Bvv6Row</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>QUATTRINI, A</creator><creator>COMI, G</creator><creator>NEMNI, R</creator><creator>MARTINELLI, V</creator><creator>VILLA, A</creator><creator>CAIMI, M</creator><creator>WRABETZ, L</creator><creator>CANAL, N</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19971101</creationdate><title>Axonal neuropathy associated with interferon-α treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells</title><author>QUATTRINI, A ; COMI, G ; NEMNI, R ; MARTINELLI, V ; VILLA, A ; CAIMI, M ; WRABETZ, L ; CANAL, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-4a93ed4a0817cf43dd988e45ad16378b9babe3b66a67d95c81bd4a33fc112b623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Axons - physiology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Fluorescent Antibody Technique, Direct</topic><topic>Hepatitis</topic><topic>Hepatitis C</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - drug therapy</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA-DR Antigens - metabolism</topic><topic>Humans</topic><topic>Immunofluorescence</topic><topic>Immunohistochemistry</topic><topic>Immunoreactivity</topic><topic>Interferon</topic><topic>Interferon Type I - adverse effects</topic><topic>Interferon Type I - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myelin</topic><topic>Nerve Fibers, Myelinated - physiology</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>Neural Conduction - physiology</topic><topic>Paresthesia</topic><topic>Peripheral Nervous System Diseases - chemically induced</topic><topic>Peripheral Nervous System Diseases - pathology</topic><topic>Peripheral neuropathy</topic><topic>Pharmacology. Drug treatments</topic><topic>Recombinant Proteins</topic><topic>Schwann cells</topic><topic>Schwann Cells - metabolism</topic><topic>Sural nerve</topic><topic>Sural Nerve - pathology</topic><topic>Sural Nerve - ultrastructure</topic><topic>Toxicity: nervous system and muscle</topic><topic>α-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>QUATTRINI, A</creatorcontrib><creatorcontrib>COMI, G</creatorcontrib><creatorcontrib>NEMNI, R</creatorcontrib><creatorcontrib>MARTINELLI, V</creatorcontrib><creatorcontrib>VILLA, A</creatorcontrib><creatorcontrib>CAIMI, M</creatorcontrib><creatorcontrib>WRABETZ, L</creatorcontrib><creatorcontrib>CANAL, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>QUATTRINI, A</au><au>COMI, G</au><au>NEMNI, R</au><au>MARTINELLI, V</au><au>VILLA, A</au><au>CAIMI, M</au><au>WRABETZ, L</au><au>CANAL, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Axonal neuropathy associated with interferon-α treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>94</volume><issue>5</issue><spage>504</spage><epage>508</epage><pages>504-508</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9386785</pmid><doi>10.1007/s004010050740</doi><tpages>5</tpages></addata></record> |
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| ispartof | Acta neuropathologica, 1997-11, Vol.94 (5), p.504-508 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Axons - physiology Biological and medical sciences Biopsy Drug toxicity and drugs side effects treatment Fluorescent Antibody Technique, Direct Hepatitis Hepatitis C Hepatitis C - complications Hepatitis C - drug therapy Histocompatibility antigen HLA HLA-DR Antigens - metabolism Humans Immunofluorescence Immunohistochemistry Immunoreactivity Interferon Interferon Type I - adverse effects Interferon Type I - therapeutic use Male Medical sciences Myelin Nerve Fibers, Myelinated - physiology Nerve Fibers, Myelinated - ultrastructure Neural Conduction - physiology Paresthesia Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - pathology Peripheral neuropathy Pharmacology. Drug treatments Recombinant Proteins Schwann cells Schwann Cells - metabolism Sural nerve Sural Nerve - pathology Sural Nerve - ultrastructure Toxicity: nervous system and muscle α-Interferon |
| title | Axonal neuropathy associated with interferon-α treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells |
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