Axonal neuropathy associated with interferon-α treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells

A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biops...

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Veröffentlicht in:	Acta neuropathologica 1997-11, Vol.94 (5), p.504-508
Hauptverfasser:	QUATTRINI, A, COMI, G, NEMNI, R, MARTINELLI, V, VILLA, A, CAIMI, M, WRABETZ, L, CANAL, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Axons - physiology Biological and medical sciences Biopsy Drug toxicity and drugs side effects treatment Fluorescent Antibody Technique, Direct Hepatitis Hepatitis C Hepatitis C - complications Hepatitis C - drug therapy Histocompatibility antigen HLA HLA-DR Antigens - metabolism Humans Immunofluorescence Immunohistochemistry Immunoreactivity Interferon Interferon Type I - adverse effects Interferon Type I - therapeutic use Male Medical sciences Myelin Nerve Fibers, Myelinated - physiology Nerve Fibers, Myelinated - ultrastructure Neural Conduction - physiology Paresthesia Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - pathology Peripheral neuropathy Pharmacology. Drug treatments Recombinant Proteins Schwann cells Schwann Cells - metabolism Sural nerve Sural Nerve - pathology Sural Nerve - ultrastructure Toxicity: nervous system and muscle α-Interferon
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Beschreibung
Zusammenfassung:	A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
ISSN:	0001-6322 1432-0533
DOI:	10.1007/s004010050740