Mitochondrial biogenesis: The Tom and Tim machine

Mitochondrial biogenesis: The Tom and Tim machine

Translocation of precursor proteins into mitochondria depends on loosely assembled protein complexes in the outer and inner membranes. Recent studies indicate that dynamic interactions of subcomplexes and cooperation with molecular chaperones drive key steps in protein import.

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Veröffentlicht in:Current biology 1997-02, Vol.7 (2), p.R100-R103
Hauptverfasser: Pfanner, Nikolaus, Meijer, Michiel
Format: Artikel
Sprache:eng
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Zusammenfassung:Translocation of precursor proteins into mitochondria depends on loosely assembled protein complexes in the outer and inner membranes. Recent studies indicate that dynamic interactions of subcomplexes and cooperation with molecular chaperones drive key steps in protein import.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(06)00048-0