A Crystal Structure of an Oligoproline PPII-Helix, at Last

A Crystal Structure of an Oligoproline PPII-Helix, at Last

The first crystal structure of an oligoproline adopting an all-trans polyproline II (PPII) helix is presented. The high-resolution structure provides detailed insight into the dimensions and conformational properties of oligoprolines that are important for, e.g., their use as “molecular rulers” and...

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Veröffentlicht in:Journal of the American Chemical Society 2014-11, Vol.136 (45), p.15829-15832
Hauptverfasser: Wilhelm, Patrick, Lewandowski, Bartosz, Trapp, Nils, Wennemers, Helma
Format: Artikel
Sprache:eng
Schlagworte:
Crystallography, X-Ray
Models, Molecular
Peptides - chemistry
Protein Structure, Secondary
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Zusammenfassung:The first crystal structure of an oligoproline adopting an all-trans polyproline II (PPII) helix is presented. The high-resolution structure provides detailed insight into the dimensions and conformational properties of oligoprolines that are important for, e.g., their use as “molecular rulers” and “molecular scaffolds”. The structure also showed that the amides interact with each other within a PPII helix and that water is not necessary for PPII helicity.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja507405j