Treatment of Children and Young Adults with Early-Stage Non-Hodgkin's Lymphoma

The improvement over the past two decades in the outcome for children and young adults with non-Hodgkin's lymphoma is one of the success stories of pediatric oncology. Nearly three fourths of all children and young adults with this disease who undergo current therapeutic regimens are cured, including most of those who present with local or regional (early-stage) disease confined to sites associated with a favorable prognosis. 1 – 7 Because of a desire to spare young patients with early-stage non-Hodgkin's lymphoma from the adverse acute and late effects of therapy, we conducted two consecutive studies designed to maintain the high cure rate . . .