Synthesis of (−)-Haliclonadiamine
Diastereoselective and enantioselective hydrogenation of the racemic β-keto ester 5 to give the enantiomerically pure (96% ee) ester 8 is reported. The conversion of the derived vinylstannane 11 to the antibiotic marine alkaloid (−)-haliclonadiamine (1) is described.
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| Veröffentlicht in: | Journal of the American Chemical Society 1997-01, Vol.119 (1), p.22-26 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Diastereoselective and enantioselective hydrogenation of the racemic β-keto ester 5 to give the enantiomerically pure (96% ee) ester 8 is reported. The conversion of the derived vinylstannane 11 to the antibiotic marine alkaloid (−)-haliclonadiamine (1) is described. |
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| ISSN: | 0002-7863 1520-5126 |
| DOI: | 10.1021/ja962162u |