Synergistic Antiproliferative Effect of Interferons and Azidothymidine on HL60 Cells
Proliferation of human leukemia cells, HL60, was synergistically inhibited by a combination of human interferons and azidothymidine in vitro. Combination of interferon-γ (3000U/ml) and azidothymidine (30μM) inhibited cell growth by 76%, whereas interferon-γ alone suppressed growth by 23% and azidoth...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1992/03/25, Vol.40(3), pp.821-822 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | NAKAE, Hiroko ASADA, Shozo |
| description | Proliferation of human leukemia cells, HL60, was synergistically inhibited by a combination of human interferons and azidothymidine in vitro. Combination of interferon-γ (3000U/ml) and azidothymidine (30μM) inhibited cell growth by 76%, whereas interferon-γ alone suppressed growth by 23% and azidothymidine alone by 33%. Interferon-α-2a and interferon-β also exerted synergistic effects with azidothymidine, but the potentiation was weaker then that by the combination of interferon-γ and aziodthymidine. |
| doi_str_mv | 10.1248/cpb.40.821 |
| format | Article |
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Combination of interferon-γ (3000U/ml) and azidothymidine (30μM) inhibited cell growth by 76%, whereas interferon-γ alone suppressed growth by 23% and azidothymidine alone by 33%. Interferon-α-2a and interferon-β also exerted synergistic effects with azidothymidine, but the potentiation was weaker then that by the combination of interferon-γ and aziodthymidine.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.40.821</identifier><identifier>PMID: 1377102</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Antineoplastic agents ; azidothymidine ; Biological and medical sciences ; Cell Division - drug effects ; Drug Synergism ; General aspects ; HL60 ; Humans ; interferon ; Interferon alpha-2 ; Interferon-alpha - pharmacology ; Interferon-beta - pharmacology ; Interferon-gamma - pharmacology ; Interferons - pharmacology ; Leukemia, Experimental - pathology ; Medical sciences ; Pharmacology. Drug treatments ; Recombinant Proteins ; synergistic inhibition ; Tumor Cells, Cultured ; Zidovudine - pharmacology</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1992/03/25, Vol.40(3), pp.821-822</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5201-ba370a9f5a561932fe1a232ac60feaa02abfb90f61dcd8a8b7fc7fd759482fae3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5406462$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1377102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAKAE, Hiroko</creatorcontrib><creatorcontrib>ASADA, Shozo</creatorcontrib><title>Synergistic Antiproliferative Effect of Interferons and Azidothymidine on HL60 Cells</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Proliferation of human leukemia cells, HL60, was synergistically inhibited by a combination of human interferons and azidothymidine in vitro. Combination of interferon-γ (3000U/ml) and azidothymidine (30μM) inhibited cell growth by 76%, whereas interferon-γ alone suppressed growth by 23% and azidothymidine alone by 33%. Interferon-α-2a and interferon-β also exerted synergistic effects with azidothymidine, but the potentiation was weaker then that by the combination of interferon-γ and aziodthymidine.</description><subject>Antineoplastic agents</subject><subject>azidothymidine</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Drug Synergism</subject><subject>General aspects</subject><subject>HL60</subject><subject>Humans</subject><subject>interferon</subject><subject>Interferon alpha-2</subject><subject>Interferon-alpha - pharmacology</subject><subject>Interferon-beta - pharmacology</subject><subject>Interferon-gamma - pharmacology</subject><subject>Interferons - pharmacology</subject><subject>Leukemia, Experimental - pathology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Recombinant Proteins</subject><subject>synergistic inhibition</subject><subject>Tumor Cells, Cultured</subject><subject>Zidovudine - pharmacology</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1rGzEQhkVpSZy0l94LOpQeAuuOpNV-HI1xk4Chh6ZnMasdJQprrSOtC86vr8ya5KIBvQ_zDg9jXwUshSybn3bfLUtYNlJ8YAuhyrrQUqqPbAEAbSFVpS7ZVUrPAFJDrS7YhVB1LUAu2MOfY6D46NPkLV-Fye_jOHhHESf_j_jGObITHx2_DxPF_D-GxDH0fPXq-3F6Ou587wPxMfC7bQV8TcOQPrNPDodEX87zmv39tXlY3xXb37f369W2sFqCKDpUNWDrNOpKtEo6EiiVRFuBI0SQ2LmuBVeJ3vYNNl3tbO36WrdlIx2SumY_5r356JcDpcnsfLL5Agw0HpIRlVRaljKDNzNo45hSJGf20e8wHo0Ac1JoskJTgskKM_ztvPXQ7ah_R2dnOf9-zjFZHFzEYH16w3QJVVmdsPWMPacJH-ktx5hVD3RqFK1uTq1qfnL5e_qE0VBQ_wGYJJFj</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>NAKAE, Hiroko</creator><creator>ASADA, Shozo</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope></search><sort><creationdate>1992</creationdate><title>Synergistic Antiproliferative Effect of Interferons and Azidothymidine on HL60 Cells</title><author>NAKAE, Hiroko ; ASADA, Shozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5201-ba370a9f5a561932fe1a232ac60feaa02abfb90f61dcd8a8b7fc7fd759482fae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antineoplastic agents</topic><topic>azidothymidine</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Drug Synergism</topic><topic>General aspects</topic><topic>HL60</topic><topic>Humans</topic><topic>interferon</topic><topic>Interferon alpha-2</topic><topic>Interferon-alpha - pharmacology</topic><topic>Interferon-beta - pharmacology</topic><topic>Interferon-gamma - pharmacology</topic><topic>Interferons - pharmacology</topic><topic>Leukemia, Experimental - pathology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Recombinant Proteins</topic><topic>synergistic inhibition</topic><topic>Tumor Cells, Cultured</topic><topic>Zidovudine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAKAE, Hiroko</creatorcontrib><creatorcontrib>ASADA, Shozo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAKAE, Hiroko</au><au>ASADA, Shozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic Antiproliferative Effect of Interferons and Azidothymidine on HL60 Cells</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1992</date><risdate>1992</risdate><volume>40</volume><issue>3</issue><spage>821</spage><epage>822</epage><pages>821-822</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Proliferation of human leukemia cells, HL60, was synergistically inhibited by a combination of human interferons and azidothymidine in vitro. Combination of interferon-γ (3000U/ml) and azidothymidine (30μM) inhibited cell growth by 76%, whereas interferon-γ alone suppressed growth by 23% and azidothymidine alone by 33%. Interferon-α-2a and interferon-β also exerted synergistic effects with azidothymidine, but the potentiation was weaker then that by the combination of interferon-γ and aziodthymidine.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>1377102</pmid><doi>10.1248/cpb.40.821</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1992/03/25, Vol.40(3), pp.821-822 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Antineoplastic agents azidothymidine Biological and medical sciences Cell Division - drug effects Drug Synergism General aspects HL60 Humans interferon Interferon alpha-2 Interferon-alpha - pharmacology Interferon-beta - pharmacology Interferon-gamma - pharmacology Interferons - pharmacology Leukemia, Experimental - pathology Medical sciences Pharmacology. Drug treatments Recombinant Proteins synergistic inhibition Tumor Cells, Cultured Zidovudine - pharmacology |
| title | Synergistic Antiproliferative Effect of Interferons and Azidothymidine on HL60 Cells |
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