Synergistic Antiproliferative Effect of Interferons and Azidothymidine on HL60 Cells

Proliferation of human leukemia cells, HL60, was synergistically inhibited by a combination of human interferons and azidothymidine in vitro. Combination of interferon-γ (3000U/ml) and azidothymidine (30μM) inhibited cell growth by 76%, whereas interferon-γ alone suppressed growth by 23% and azidoth...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/03/25, Vol.40(3), pp.821-822
Hauptverfasser:	NAKAE, Hiroko, ASADA, Shozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents azidothymidine Biological and medical sciences Cell Division - drug effects Drug Synergism General aspects HL60 Humans interferon Interferon alpha-2 Interferon-alpha - pharmacology Interferon-beta - pharmacology Interferon-gamma - pharmacology Interferons - pharmacology Leukemia, Experimental - pathology Medical sciences Pharmacology. Drug treatments Recombinant Proteins synergistic inhibition Tumor Cells, Cultured Zidovudine - pharmacology
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Beschreibung
Zusammenfassung:	Proliferation of human leukemia cells, HL60, was synergistically inhibited by a combination of human interferons and azidothymidine in vitro. Combination of interferon-γ (3000U/ml) and azidothymidine (30μM) inhibited cell growth by 76%, whereas interferon-γ alone suppressed growth by 23% and azidothymidine alone by 33%. Interferon-α-2a and interferon-β also exerted synergistic effects with azidothymidine, but the potentiation was weaker then that by the combination of interferon-γ and aziodthymidine.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.40.821