Lacidipine: A dihydropyridine calcium antagonist with antioxidant activity

Lacipidine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in series of tests that consider specific species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain...

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Veröffentlicht in:	Free radical biology & medicine 1992, Vol.12 (3), p.183-187
Hauptverfasser:	van Amsterdam, Frank Th.M., Roveri, Antonella, Maiorino, Matilde, Ratti, Emiliangelo, Ursini, Fulvio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Calcium blocker Calcium Channel Blockers - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism Cerebral Cortex - drug effects Cerebral Cortex - metabolism Dihydropyridines - pharmacology Drug Interactions Free Radicals Hypertension Lacidipine Lipid peroxidation Lipid Peroxidation - drug effects Male Oxidants Rats Rats, Inbred Strains Superoxides - chemistry
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Zusammenfassung:	Lacipidine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in series of tests that consider specific species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E.
ISSN:	0891-5849 1873-4596
DOI:	10.1016/0891-5849(92)90025-C