A possible role for NKT-like cells in patients with chronic hepatitis B during telbivudine treatment

Highlights • NKT-like cell frequency positively correlates with HBV DNA in patients with CHB. • NKT-like cell frequency decreases in patients who respond to telbivudine. • NKT-like cell frequency positively correlates with serum IL-17 in CHB patients. • NKT-like cells may be a immunologic marker of...

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Veröffentlicht in:	Immunology letters 2014-07, Vol.160 (1), p.65-71
Hauptverfasser:	Diao, Hongyan, He, Jianqin, Zheng, Qishi, Chen, Jianing, Cui, Guangying, Wei, Yingfeng, Ye, Ping, Kohanawa, Masashi, Li, Lanjuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Antiviral Agents - therapeutic use Chronic hepatitis B Female Hepatitis B virus Hepatitis B virus - immunology Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - immunology Hepatitis B, Chronic - virology Humans IL-17 Immunophenotyping Interleukin-17 - biosynthesis Lymphocyte Count Male Middle Aged Natural Killer T-Cells - drug effects Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism NKT-like cells T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Telbivudine treatment Thymidine - analogs & derivatives Thymidine - therapeutic use Treatment Outcome Viral Load Young Adult
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Zusammenfassung:	Highlights • NKT-like cell frequency positively correlates with HBV DNA in patients with CHB. • NKT-like cell frequency decreases in patients who respond to telbivudine. • NKT-like cell frequency positively correlates with serum IL-17 in CHB patients. • NKT-like cells may be a immunologic marker of the efficacy of anti-HBV therapy. • NKT-like cells may be an important source of IL-17 in patients with CHB.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2014.03.013