Characterization and immunogenicity in mice of recombinant influenza haemagglutinins produced in Leishmania tarentolae

Highlights • Six different haemagglutinin proteins from influenza were produced in L. tarentolae. • Expression and purification of the haemagglutinin proteins were easy. • Haemagglutinin proteins were immunogenic in mice. • L. tarentolae could be an alternative to influenza egg-based vaccines....

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Veröffentlicht in:	Vaccine 2014-09, Vol.32 (43), p.5570-5576
Hauptverfasser:	Pion, Corinne, Courtois, Virginie, Husson, Stéphanie, Bernard, Marie-Clotilde, Nicolai, Marie-Claire, Talaga, Philippe, Trannoy, Emanuelle, Moste, Catherine, Sodoyer, Régis, Legastelois, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Viral - blood Applied microbiology Biological and medical sciences Cloning, Molecular Female Fundamental and applied biological sciences. Psychology Haemagglutinin Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - biosynthesis Hemagglutinin Glycoproteins, Influenza Virus - immunology Immunoglobulin G - blood Influenza Influenza A Virus, H1N1 Subtype Influenza Vaccines - immunology Lacertilia Leishmania - metabolism Leishmania tarentolae Mice, Inbred BALB C Microbiology Orthomyxoviridae Infections - prevention & control Recombinant Proteins - biosynthesis Recombinant Proteins - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:	Highlights • Six different haemagglutinin proteins from influenza were produced in L. tarentolae. • Expression and purification of the haemagglutinin proteins were easy. • Haemagglutinin proteins were immunogenic in mice. • L. tarentolae could be an alternative to influenza egg-based vaccines.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.07.092