T lymphocytes subsets and cytokine pattern induced by vaccination against bovine brucellosis employing S19 calfhood vaccination and adult RB51 revaccination

Highlights • CD4+ and CD8+ T-lymphocytes proliferate following brucellosis vaccination in cattle. • CD4+ T-cells are the main source of IFN-γ after brucellosis vaccination. • IL-4 production does not seem to be induced in cattle following brucellosis vaccination. • RB51 revaccination does not seem e...

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Veröffentlicht in:	Vaccine 2014-10, Vol.32 (46), p.6034-6038
Hauptverfasser:	Dorneles, Elaine M.S, Teixeira-Carvalho, Andréa, Araújo, Márcio S.S, Lima, Graciela Kunrath, Martins-Filho, Olindo A, Sriranganathan, Nammalwar, Lage, Andrey P
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigens Applied microbiology Bacterial diseases Biological and medical sciences Brucella abortus Brucella Vaccine - immunology Brucellosis Brucellosis, Bovine - prevention & control Calfhood vaccination Cattle CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cellular immunity Cytokines - immunology Data analysis Female Fundamental and applied biological sciences. Psychology Human bacterial diseases Immune response Immunization, Secondary Infectious diseases Interferon-gamma - immunology Interleukin-4 - immunology Lymphocytes Medical sciences Microbiology Miscellaneous Pregnancy RB51 Revaccination of pregnant cattle S19 Software Studies Vaccination - veterinary Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:	Highlights • CD4+ and CD8+ T-lymphocytes proliferate following brucellosis vaccination in cattle. • CD4+ T-cells are the main source of IFN-γ after brucellosis vaccination. • IL-4 production does not seem to be induced in cattle following brucellosis vaccination. • RB51 revaccination does not seem enhance immunity of S19 calfhood vaccinated cows.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.08.060