Biochemical and immunological studies on erythrocytes superoxide dismutase modified by nitric oxide in patients with alopecia areata: Implications in alopecia patchy persistent and alopecia universalis

Highlights • This study demonstrates the role of NO-modified erythrocytes SOD in AA. • Modification in eSOD by NO caused alteration in hydrophobic amino acids. • NO-induced epitopes on eSOD are strongly recognized by alopecia universalis-IgG. • NO-eSOD specific IgG in AA patients was increased as AU...

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Veröffentlicht in:	Immunology letters 2014-07, Vol.160 (1), p.50-57
Hauptverfasser:	Rasheed, Zafar, Alzolibani, Abdullateef A, Al-Shobaili, Hani A, Saif, Ghada Bin, Al Robaee, Ahmad A
Format:	Artikel
Sprache:	eng
Schlagworte:	AA autoimmunity Adult Allergy and Immunology Alopecia - immunology Alopecia - metabolism Alopecia areata Alopecia Areata - immunology Alopecia Areata - metabolism Alopecia patchy persistent Alopecia universalis Enzyme Activation - drug effects Erythrocytes - drug effects Erythrocytes - metabolism Erythrocytes superoxide dismutase Female Humans Immunoglobulin G - immunology Male Middle Aged Nitric oxide Nitric Oxide - metabolism Nitric Oxide - pharmacology NO-eSOD Oxidation-Reduction Superoxide Dismutase - immunology Superoxide Dismutase - metabolism Young Adult
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Zusammenfassung:	Highlights • This study demonstrates the role of NO-modified erythrocytes SOD in AA. • Modification in eSOD by NO caused alteration in hydrophobic amino acids. • NO-induced epitopes on eSOD are strongly recognized by alopecia universalis-IgG. • NO-eSOD specific IgG in AA patients was increased as AU-IgG > AAP-IgG > control-IgG. • AU patients’ sera contain higher levels of carbonyl contents and NO.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2014.03.007