Association of single-nucleotide polymorphisms in TLR7 (Gln11Leu) and TLR9 (1635A/G) with a higher CD4T cell count during HIV infection

Highlights • A trend toward linking TLR7 Gln (AA) genotype to a normal CD4 count after viremia. • Patients with TLR9 1635 (AG) genotype had the highest CD4 count during viremia. • Patients with TLR9 1635 (GG) genotype had the lowest CD4 count during viremia. • Combining TLR7 Gln (AA)/ TLR9 1635 (AG)...

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Veröffentlicht in:	Immunology letters 2014-07, Vol.160 (1), p.58-64
Hauptverfasser:	Said, E.A, Al-Yafei, F, Zadjali, F, Hasson, S.S, Al-Balushi, M.S, Al-Mahruqi, S, Koh, C.Y, Al-Naamani, K, Al-Busaidi, J.Z, Idris, M.A, Balkhair, A, Al-Jabri, A.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Allergy and Immunology Amino Acid Substitution Antiretroviral Therapy, Highly Active Case-Control Studies CD4 Lymphocyte Count CD4T cells Female Gene Frequency Genotype HIV HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Male Middle Aged Polymorphism, Single Nucleotide Single nucleotide polymorphism (SNP) Toll-like receptor Toll-Like Receptor 7 - genetics Toll-Like Receptor 9 - genetics Viral Load Viremic
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Zusammenfassung:	Highlights • A trend toward linking TLR7 Gln (AA) genotype to a normal CD4 count after viremia. • Patients with TLR9 1635 (AG) genotype had the highest CD4 count during viremia. • Patients with TLR9 1635 (GG) genotype had the lowest CD4 count during viremia. • Combining TLR7 Gln (AA)/ TLR9 1635 (AG) genotypes might be related to a higher CD4 count.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2014.04.005