Osteoclast progenitors promote bone vascularization and osteogenesis

Preosteoclasts give rise to bone-resorbing osteoclasts, which are crucial for skeletal homeostasis. A study now shows that preosteoclasts also contribute to bone formation by releasing platelet-derived growth factor-BB, which promotes bone vascularization and osteogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2014-11, Vol.20 (11), p.1238-1240
Hauptverfasser:	Kusumbe, Anjali P., Adams, Ralf H.
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/1426 Analysis Animals Biomedicine Bones Cancer Research Female Homeostasis Infectious Diseases Metabolic Diseases Molecular Medicine Neovascularization, Physiologic Neurosciences news-and-views Osteoclasts (Biology) Osteoclasts - secretion Osteogenesis Physiological aspects Proto-Oncogene Proteins c-sis - secretion Skeletal system Stem cells
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Beschreibung
Zusammenfassung:	Preosteoclasts give rise to bone-resorbing osteoclasts, which are crucial for skeletal homeostasis. A study now shows that preosteoclasts also contribute to bone formation by releasing platelet-derived growth factor-BB, which promotes bone vascularization and osteogenesis.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm.3747