ABO Blood Group Antibody Levels in Infants Exposed to Mechanical Circulatory Support

ABO Blood Group Antibody Levels in Infants Exposed to Mechanical Circulatory Support

ABO sensitization is a barrier to ABO-incompatible heart transplantation in infants. We investigate the development of ABO antibodies in infants with and without mechanical circulatory support (MCS) during their waiting period. Although the proportion of patients with antibodies was similar between...

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Veröffentlicht in:ASAIO journal (1992) 2014-11, Vol.60 (6), p.737-739
Hauptverfasser: Guynes, Anthony, Delaney, Meghan, McMullan, David M, Townsend-McCall, Dee, Kemna, Mariska, Boucek, Robert, Law, Yuk M
Format: Artikel
Sprache:eng
Schlagworte:
ABO Blood-Group System
Blood Group Incompatibility - complications
Blood Group Incompatibility - immunology
Child, Preschool
Cohort Studies
Extracorporeal Membrane Oxygenation - adverse effects
Female
Graft Rejection - etiology
Graft Rejection - immunology
Heart Transplantation - adverse effects
Heart-Assist Devices - adverse effects
Humans
Infant
Infant, Newborn
Isoantibodies - blood
Male
Retrospective Studies
Risk Factors
Time Factors
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Zusammenfassung:ABO sensitization is a barrier to ABO-incompatible heart transplantation in infants. We investigate the development of ABO antibodies in infants with and without mechanical circulatory support (MCS) during their waiting period. Although the proportion of patients with antibodies was similar between the groups, the median age at antibody detection was only 9 days (6–198) for MCS vs. 223 days (28–367) for non-MCS patients (P = 0.028), suggesting MCS is associated with earlier ABO antibody detection.
ISSN:1058-2916
1538-943X
DOI:10.1097/MAT.0000000000000130