Modulation of N-methyl- N′-nitro- N-nitrosoguanidine induced inhibition of cell-free protein synthesis by sulfur compounds
We report here the influence of PDTC, DDTC, GSH and GS-DDTC on ( super(14)C)amino acid incorporation into protein using rat liver postmitochondrial supernatant (S30 fraction) in an in vitro protein synthesizing system.
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Veröffentlicht in: | Biochemical pharmacology 1991-10, Vol.42 (10), p.2065-2067 |
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container_title | Biochemical pharmacology |
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creator | Bagewadikar, Raghavendra Bertram, Barbara Frank, Norbert Wiessler, Manfred |
description | We report here the influence of PDTC, DDTC, GSH and GS-DDTC on ( super(14)C)amino acid incorporation into protein using rat liver postmitochondrial supernatant (S30 fraction) in an in vitro protein synthesizing system. |
doi_str_mv | 10.1016/0006-2952(91)90613-A |
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subjects | Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell-Free System - drug effects Chemical agents Ditiocarb - pharmacology Drug Interactions Glutathione - pharmacology Liver - drug effects Liver - metabolism Male Medical sciences Methylnitronitrosoguanidine - antagonists & inhibitors Methylnitronitrosoguanidine - pharmacology Proline - analogs & derivatives Proline - pharmacology Protein Biosynthesis Rats Rats, Inbred Strains Thiocarbamates - pharmacology Tumors |
title | Modulation of N-methyl- N′-nitro- N-nitrosoguanidine induced inhibition of cell-free protein synthesis by sulfur compounds |
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