Modulation of N-methyl- N′-nitro- N-nitrosoguanidine induced inhibition of cell-free protein synthesis by sulfur compounds

We report here the influence of PDTC, DDTC, GSH and GS-DDTC on ( super(14)C)amino acid incorporation into protein using rat liver postmitochondrial supernatant (S30 fraction) in an in vitro protein synthesizing system.

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Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 1991-10, Vol.42 (10), p.2065-2067
Hauptverfasser:	Bagewadikar, Raghavendra, Bertram, Barbara, Frank, Norbert, Wiessler, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell-Free System - drug effects Chemical agents Ditiocarb - pharmacology Drug Interactions Glutathione - pharmacology Liver - drug effects Liver - metabolism Male Medical sciences Methylnitronitrosoguanidine - antagonists & inhibitors Methylnitronitrosoguanidine - pharmacology Proline - analogs & derivatives Proline - pharmacology Protein Biosynthesis Rats Rats, Inbred Strains Thiocarbamates - pharmacology Tumors
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Beschreibung
Zusammenfassung:	We report here the influence of PDTC, DDTC, GSH and GS-DDTC on ( super(14)C)amino acid incorporation into protein using rat liver postmitochondrial supernatant (S30 fraction) in an in vitro protein synthesizing system.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(91)90613-A