Understanding the mechanisms of action of antiangiogenic agents in metastatic colorectal cancer: A clinician’s perspective

Highlights • Mechanisms of action of antiangiogenic agents in metastatic colorectal cancer are reviewed. • Preclinical data and clinical evidence are examined for each agent. • We highlight distinctions in biological mechanism between therapies. • Future directions of targeted antiangiogenic agents...

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Veröffentlicht in:	Cancer treatment reviews 2014-10, Vol.40 (9), p.1065-1072
Hauptverfasser:	Clarke, J.M, Hurwitz, H.I, Rangwala, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Antiangiogenic Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic agents Bevacizumab Biological and medical sciences Clinical Trials, Phase III as Topic Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Drug Screening Assays, Antitumor Gastroenterology. Liver. Pancreas. Abdomen Hematology, Oncology and Palliative Medicine Humans Medical sciences Metastatic colorectal cancer Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pharmacology. Drug treatments Phenylurea Compounds - therapeutic use Pyridines - therapeutic use Ramucirumab Receptors, Vascular Endothelial Growth Factor - therapeutic use Recombinant Fusion Proteins - therapeutic use Regorafenib Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Microenvironment - drug effects Tumors Ziv-aflibercept
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Zusammenfassung:	Highlights • Mechanisms of action of antiangiogenic agents in metastatic colorectal cancer are reviewed. • Preclinical data and clinical evidence are examined for each agent. • We highlight distinctions in biological mechanism between therapies. • Future directions of targeted antiangiogenic agents are discussed.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2014.07.001