Construction of Erythrinane Skeleton via Pd(0)-Catalyzed Intramolecular Dearomatization of para-Aminophenols

Construction of Erythrinane Skeleton via Pd(0)-Catalyzed Intramolecular Dearomatization of para-Aminophenols

A novel Pd(0)-catalyzed intramolecular arylative dearomatization of para-aminophenol derivatives is described. In the presence of 1.25 mol % [Pd­(C3H5)­Cl]2 and 3.75 mol % RuPhos, the arylative dearomatization reaction proceeds smoothly for a broad range of substrates, offering an efficient syntheti...

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Veröffentlicht in:Journal of the American Chemical Society 2014-11, Vol.136 (44), p.15469-15472
Hauptverfasser: Xu, Ren-Qi, Gu, Qing, Wu, Wen-Ting, Zhao, Zhuo-An, You, Shu-Li
Format: Artikel
Sprache:eng
Schlagworte:
Aminophenols - chemistry
Catalysis
Palladium - chemistry
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Zusammenfassung:A novel Pd(0)-catalyzed intramolecular arylative dearomatization of para-aminophenol derivatives is described. In the presence of 1.25 mol % [Pd­(C3H5)­Cl]2 and 3.75 mol % RuPhos, the arylative dearomatization reaction proceeds smoothly for a broad range of substrates, offering an efficient synthetic route to erythrinane derivatives in excellent yields.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja508645j