c-fos mRNA in mouse brain after MPTP treatment

The neurotoxin, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a transient increase of mRNA for the immediate-early gene c-fos in the mouse brain. The c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus...

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Veröffentlicht in:	Neurochemistry international 1992-04, Vol.20 (3), p.281-287
Hauptverfasser:	Duchemin, A.M., Gudehithlu, K.P., Neff, N.H., Hadjiconstantinou, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Biochemistry and metabolism Biological and medical sciences Blotting, Northern Brain - drug effects Brain - metabolism Central nervous system Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Genes, fos Kinetics Male Mazindol - pharmacology Mice Neurotoxins - pharmacology Organ Specificity Pargyline - pharmacology Reference Values RNA - isolation & purification RNA, Messenger - metabolism Selegiline - pharmacology Time Factors Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
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