c-fos mRNA in mouse brain after MPTP treatment

c-fos mRNA in mouse brain after MPTP treatment

The neurotoxin, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a transient increase of mRNA for the immediate-early gene c-fos in the mouse brain. The c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus...

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Veröffentlicht in:Neurochemistry international 1992-04, Vol.20 (3), p.281-287
Hauptverfasser: Duchemin, A.M., Gudehithlu, K.P., Neff, N.H., Hadjiconstantinou, M.
Format: Artikel
Sprache:eng
Schlagworte:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology
Animals
Biochemistry and metabolism
Biological and medical sciences
Blotting, Northern
Brain - drug effects
Brain - metabolism
Central nervous system
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Genes, fos
Kinetics
Male
Mazindol - pharmacology
Mice
Neurotoxins - pharmacology
Organ Specificity
Pargyline - pharmacology
Reference Values
RNA - isolation & purification
RNA, Messenger - metabolism
Selegiline - pharmacology
Time Factors
Vertebrates: nervous system and sense organs
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Zusammenfassung:The neurotoxin, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a transient increase of mRNA for the immediate-early gene c-fos in the mouse brain. The c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus, cerebellum and midbrain. There are regional differences in the time-course for the rise of c-fos mRNA. Pretreatment with deprenyl, a selective monoamine oxidase B inhibitor, pargyline, a nonselective monoamine oxidase inhibitor, or mazindol, a dopamine uptake transport inhibitor, does not prevent the c-fos mRNA increase, suggesting that the elevation is due to the action of MPTP and not its neurotoxic metabolite MPP +.
ISSN:0197-0186
1872-9754
DOI:10.1016/0197-0186(92)90042-P