c-fos mRNA in mouse brain after MPTP treatment
The neurotoxin, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a transient increase of mRNA for the immediate-early gene c-fos in the mouse brain. The c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus...
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| Veröffentlicht in: | Neurochemistry international 1992-04, Vol.20 (3), p.281-287 |
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| creator | Duchemin, A.M. Gudehithlu, K.P. Neff, N.H. Hadjiconstantinou, M. |
| description | The neurotoxin, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a transient increase of mRNA for the immediate-early gene
c-fos in the mouse brain. The
c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus, cerebellum and midbrain. There are regional differences in the time-course for the rise of
c-fos mRNA. Pretreatment with deprenyl, a selective monoamine oxidase B inhibitor, pargyline, a nonselective monoamine oxidase inhibitor, or mazindol, a dopamine uptake transport inhibitor, does not prevent the
c-fos mRNA increase, suggesting that the elevation is due to the action of MPTP and not its neurotoxic metabolite MPP
+. |
| doi_str_mv | 10.1016/0197-0186(92)90042-P |
| format | Article |
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c-fos in the mouse brain. The
c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus, cerebellum and midbrain. There are regional differences in the time-course for the rise of
c-fos mRNA. Pretreatment with deprenyl, a selective monoamine oxidase B inhibitor, pargyline, a nonselective monoamine oxidase inhibitor, or mazindol, a dopamine uptake transport inhibitor, does not prevent the
c-fos mRNA increase, suggesting that the elevation is due to the action of MPTP and not its neurotoxic metabolite MPP
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c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus, cerebellum and midbrain. There are regional differences in the time-course for the rise of
c-fos mRNA. Pretreatment with deprenyl, a selective monoamine oxidase B inhibitor, pargyline, a nonselective monoamine oxidase inhibitor, or mazindol, a dopamine uptake transport inhibitor, does not prevent the
c-fos mRNA increase, suggesting that the elevation is due to the action of MPTP and not its neurotoxic metabolite MPP
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c-fos in the mouse brain. The
c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus, cerebellum and midbrain. There are regional differences in the time-course for the rise of
c-fos mRNA. Pretreatment with deprenyl, a selective monoamine oxidase B inhibitor, pargyline, a nonselective monoamine oxidase inhibitor, or mazindol, a dopamine uptake transport inhibitor, does not prevent the
c-fos mRNA increase, suggesting that the elevation is due to the action of MPTP and not its neurotoxic metabolite MPP
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| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Biochemistry and metabolism Biological and medical sciences Blotting, Northern Brain - drug effects Brain - metabolism Central nervous system Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Genes, fos Kinetics Male Mazindol - pharmacology Mice Neurotoxins - pharmacology Organ Specificity Pargyline - pharmacology Reference Values RNA - isolation & purification RNA, Messenger - metabolism Selegiline - pharmacology Time Factors Vertebrates: nervous system and sense organs |
| title | c-fos mRNA in mouse brain after MPTP treatment |
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