Adjuvant chemotherapy after esophagectomy: Is there a role in the treatment of the lymph node positive thoracic esophageal squamous cell carcinoma?
Background Esophageal squamous cell carcinoma (ESCC) patients with regional lymph node metastases have poor prognosis after surgery. The purpose of this study was to investigate the impact of various treatment modalities on survival in these patients. Methods We retrospectively reviewed data from 34...
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| Veröffentlicht in: | Journal of surgical oncology 2014-12, Vol.110 (7), p.864-868 |
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| creator | Lyu, Xiao Huang, Jing Mao, Yousheng Liu, Yutao Feng, Qinfu Shao, Kang Gao, Shugeng Jiang, Yong Wang, Jinwan He, Jie |
| description | Background
Esophageal squamous cell carcinoma (ESCC) patients with regional lymph node metastases have poor prognosis after surgery. The purpose of this study was to investigate the impact of various treatment modalities on survival in these patients.
Methods
We retrospectively reviewed data from 349 patients who had undergone left transthoracic esophagectomy for thoracic ESCC from January 2008 to December 2010 at our institute. All patients had lesions in the mid or lower third of the thoracic segment and had pathological positive lymph node metastasis. Of these patients, 143 patients received surgery alone, 154 patients underwent postoperative radiotherapy alone, and 52 patients underwent taxane‐based chemotherapy. Univariate and multivariate Cox regression analyses were used to analyze prognostic factors and survival.
Results
At a median follow‐up of 53.1 months, the 3‐year OS were 47.7% for the patients with surgery alone, 44.0% for the patients with adjuvant radiotherapy, and 58.9% for the patients with adjuvant chemotherapy. Multivariate analysis showed that postoperative therapy with adjuvant chemotherapy was significant positive predictor of survival.
Conclusions
Postoperative taxane‐based adjuvant chemotherapy improved survival of patients with lymph node positive thoracic ESCC compared with surgery alone. Further randomized prospective studies to confirm these findings are warranted. J. Surg. Oncol. 2014 110:864–868. © 2014 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jso.23716 |
| format | Article |
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Esophageal squamous cell carcinoma (ESCC) patients with regional lymph node metastases have poor prognosis after surgery. The purpose of this study was to investigate the impact of various treatment modalities on survival in these patients.
Methods
We retrospectively reviewed data from 349 patients who had undergone left transthoracic esophagectomy for thoracic ESCC from January 2008 to December 2010 at our institute. All patients had lesions in the mid or lower third of the thoracic segment and had pathological positive lymph node metastasis. Of these patients, 143 patients received surgery alone, 154 patients underwent postoperative radiotherapy alone, and 52 patients underwent taxane‐based chemotherapy. Univariate and multivariate Cox regression analyses were used to analyze prognostic factors and survival.
Results
At a median follow‐up of 53.1 months, the 3‐year OS were 47.7% for the patients with surgery alone, 44.0% for the patients with adjuvant radiotherapy, and 58.9% for the patients with adjuvant chemotherapy. Multivariate analysis showed that postoperative therapy with adjuvant chemotherapy was significant positive predictor of survival.
Conclusions
Postoperative taxane‐based adjuvant chemotherapy improved survival of patients with lymph node positive thoracic ESCC compared with surgery alone. Further randomized prospective studies to confirm these findings are warranted. J. Surg. Oncol. 2014 110:864–868. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23716</identifier><identifier>PMID: 24976079</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; chemotherapy ; Chemotherapy, Adjuvant ; Cisplatin - administration & dosage ; Combined Modality Therapy ; esophageal cancer ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - therapy ; esophageal surgery ; Esophagectomy ; Female ; Fluorouracil - administration & dosage ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local - drug therapy ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Organoplatinum Compounds - administration & dosage ; Paclitaxel - administration & dosage ; Prognosis ; radiotherapy ; Retrospective Studies ; Survival Rate ; Taxoids - administration & dosage ; Thoracic Neoplasms - mortality ; Thoracic Neoplasms - pathology ; Thoracic Neoplasms - therapy</subject><ispartof>Journal of surgical oncology, 2014-12, Vol.110 (7), p.864-868</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4626-66a933e32bccd2805eec6790474c02b765735a784d3c96ea5d55b556f42801043</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.23716$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.23716$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24976079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyu, Xiao</creatorcontrib><creatorcontrib>Huang, Jing</creatorcontrib><creatorcontrib>Mao, Yousheng</creatorcontrib><creatorcontrib>Liu, Yutao</creatorcontrib><creatorcontrib>Feng, Qinfu</creatorcontrib><creatorcontrib>Shao, Kang</creatorcontrib><creatorcontrib>Gao, Shugeng</creatorcontrib><creatorcontrib>Jiang, Yong</creatorcontrib><creatorcontrib>Wang, Jinwan</creatorcontrib><creatorcontrib>He, Jie</creatorcontrib><title>Adjuvant chemotherapy after esophagectomy: Is there a role in the treatment of the lymph node positive thoracic esophageal squamous cell carcinoma?</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background
Esophageal squamous cell carcinoma (ESCC) patients with regional lymph node metastases have poor prognosis after surgery. The purpose of this study was to investigate the impact of various treatment modalities on survival in these patients.
Methods
We retrospectively reviewed data from 349 patients who had undergone left transthoracic esophagectomy for thoracic ESCC from January 2008 to December 2010 at our institute. All patients had lesions in the mid or lower third of the thoracic segment and had pathological positive lymph node metastasis. Of these patients, 143 patients received surgery alone, 154 patients underwent postoperative radiotherapy alone, and 52 patients underwent taxane‐based chemotherapy. Univariate and multivariate Cox regression analyses were used to analyze prognostic factors and survival.
Results
At a median follow‐up of 53.1 months, the 3‐year OS were 47.7% for the patients with surgery alone, 44.0% for the patients with adjuvant radiotherapy, and 58.9% for the patients with adjuvant chemotherapy. Multivariate analysis showed that postoperative therapy with adjuvant chemotherapy was significant positive predictor of survival.
Conclusions
Postoperative taxane‐based adjuvant chemotherapy improved survival of patients with lymph node positive thoracic ESCC compared with surgery alone. Further randomized prospective studies to confirm these findings are warranted. J. Surg. Oncol. 2014 110:864–868. © 2014 Wiley Periodicals, Inc.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cisplatin - administration & dosage</subject><subject>Combined Modality Therapy</subject><subject>esophageal cancer</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>esophageal surgery</subject><subject>Esophagectomy</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local - drug therapy</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Organoplatinum Compounds - administration & dosage</subject><subject>Paclitaxel - administration & dosage</subject><subject>Prognosis</subject><subject>radiotherapy</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Taxoids - administration & dosage</subject><subject>Thoracic Neoplasms - mortality</subject><subject>Thoracic Neoplasms - pathology</subject><subject>Thoracic Neoplasms - therapy</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctu1DAYhS0EokNhwQsgS2zYpPXdYzaoGkEp6mUBqEvL4_xDMiRxaieFPEdfuM5MmQUrX853fh37IPSWkhNKCDvdpnDCuKbqGVpQYlRhiFk-R4ussUJoQ47Qq5S2hBBjlHiJjpgwWhFtFujhrNyO964bsK-gDUMF0fUTdpsBIoYU-sr9Aj-EdvqILxKedcAOx9AArrv5jIcIbmghjwib3UUztX2Fu1AC7kOqh_o-Q1WIztf-MNM1ON2Nrg1jwh6aBnsXfd2F1n16jV5sXJPgzdN6jH5--fxj9bW4vDm_WJ1dFl4opgqlnOEcOFt7X7IlkQBe5ccKLTxha62k5tLppSi5NwqcLKVcS6k2IsOUCH6MPuzn9jHcjZAG29ZpzuI6yLEsVYzIpRaCZPT9f-g2jLHL6TJFDZeU0Zl690SN6xZK28e6dXGy_747A6d74E_dwHTQKbFzjzb3aHc92m_fb3ab7Cj2jjoN8PfgcPG3VZpraW-vz-2tXl1dr-iVpfwR2TSfoA</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Lyu, Xiao</creator><creator>Huang, Jing</creator><creator>Mao, Yousheng</creator><creator>Liu, Yutao</creator><creator>Feng, Qinfu</creator><creator>Shao, Kang</creator><creator>Gao, Shugeng</creator><creator>Jiang, Yong</creator><creator>Wang, Jinwan</creator><creator>He, Jie</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>Adjuvant chemotherapy after esophagectomy: Is there a role in the treatment of the lymph node positive thoracic esophageal squamous cell carcinoma?</title><author>Lyu, Xiao ; Huang, Jing ; Mao, Yousheng ; Liu, Yutao ; Feng, Qinfu ; Shao, Kang ; Gao, Shugeng ; Jiang, Yong ; Wang, Jinwan ; He, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4626-66a933e32bccd2805eec6790474c02b765735a784d3c96ea5d55b556f42801043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Cisplatin - administration & dosage</topic><topic>Combined Modality Therapy</topic><topic>esophageal cancer</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>esophageal surgery</topic><topic>Esophagectomy</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local - drug therapy</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Organoplatinum Compounds - administration & dosage</topic><topic>Paclitaxel - administration & dosage</topic><topic>Prognosis</topic><topic>radiotherapy</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Taxoids - administration & dosage</topic><topic>Thoracic Neoplasms - mortality</topic><topic>Thoracic Neoplasms - pathology</topic><topic>Thoracic Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyu, Xiao</creatorcontrib><creatorcontrib>Huang, Jing</creatorcontrib><creatorcontrib>Mao, Yousheng</creatorcontrib><creatorcontrib>Liu, Yutao</creatorcontrib><creatorcontrib>Feng, Qinfu</creatorcontrib><creatorcontrib>Shao, Kang</creatorcontrib><creatorcontrib>Gao, Shugeng</creatorcontrib><creatorcontrib>Jiang, Yong</creatorcontrib><creatorcontrib>Wang, Jinwan</creatorcontrib><creatorcontrib>He, Jie</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyu, Xiao</au><au>Huang, Jing</au><au>Mao, Yousheng</au><au>Liu, Yutao</au><au>Feng, Qinfu</au><au>Shao, Kang</au><au>Gao, Shugeng</au><au>Jiang, Yong</au><au>Wang, Jinwan</au><au>He, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adjuvant chemotherapy after esophagectomy: Is there a role in the treatment of the lymph node positive thoracic esophageal squamous cell carcinoma?</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>110</volume><issue>7</issue><spage>864</spage><epage>868</epage><pages>864-868</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background
Esophageal squamous cell carcinoma (ESCC) patients with regional lymph node metastases have poor prognosis after surgery. The purpose of this study was to investigate the impact of various treatment modalities on survival in these patients.
Methods
We retrospectively reviewed data from 349 patients who had undergone left transthoracic esophagectomy for thoracic ESCC from January 2008 to December 2010 at our institute. All patients had lesions in the mid or lower third of the thoracic segment and had pathological positive lymph node metastasis. Of these patients, 143 patients received surgery alone, 154 patients underwent postoperative radiotherapy alone, and 52 patients underwent taxane‐based chemotherapy. Univariate and multivariate Cox regression analyses were used to analyze prognostic factors and survival.
Results
At a median follow‐up of 53.1 months, the 3‐year OS were 47.7% for the patients with surgery alone, 44.0% for the patients with adjuvant radiotherapy, and 58.9% for the patients with adjuvant chemotherapy. Multivariate analysis showed that postoperative therapy with adjuvant chemotherapy was significant positive predictor of survival.
Conclusions
Postoperative taxane‐based adjuvant chemotherapy improved survival of patients with lymph node positive thoracic ESCC compared with surgery alone. Further randomized prospective studies to confirm these findings are warranted. J. Surg. Oncol. 2014 110:864–868. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24976079</pmid><doi>10.1002/jso.23716</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy chemotherapy Chemotherapy, Adjuvant Cisplatin - administration & dosage Combined Modality Therapy esophageal cancer Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy esophageal surgery Esophagectomy Female Fluorouracil - administration & dosage Follow-Up Studies Humans Male Middle Aged Neoplasm Grading Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Neoplasm Staging Organoplatinum Compounds - administration & dosage Paclitaxel - administration & dosage Prognosis radiotherapy Retrospective Studies Survival Rate Taxoids - administration & dosage Thoracic Neoplasms - mortality Thoracic Neoplasms - pathology Thoracic Neoplasms - therapy |
| title | Adjuvant chemotherapy after esophagectomy: Is there a role in the treatment of the lymph node positive thoracic esophageal squamous cell carcinoma? |
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