Angiogenesis in potentially malignant lesions and carcinomas during experimental oral carcinogenesis: a preliminary study in the hamster cheek pouch

To evaluate vascular morphology and density, angiogenic switch activation, vascular endothelial growth factor (VEGF) expression, and endothelial cell (EC) proliferation in the hamster cheek pouch (HCP) model of oral cancer. Immunohistochemical detection of factor VIII, 5'-Bromo-2'-Deoxyuri...

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Veröffentlicht in:	Anticancer research 2014-11, Vol.34 (11), p.6381-6388
Hauptverfasser:	Aromando, Romina F, Raimondi, Ana R, Pérez, Miguel A, Trivillin, Veronica A, Schwint, Amanda E, Itoiz, Maria E
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Apoptosis Biomarkers, Tumor - metabolism Carcinogens - toxicity Cell Proliferation Cheek - pathology Cricetinae Disease Models, Animal Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Immunoenzyme Techniques Mesocricetus Mouth Neoplasms - blood supply Mouth Neoplasms - chemically induced Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neovascularization, Pathologic - pathology Tumor Cells, Cultured Vascular Endothelial Growth Factor A - metabolism
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Zusammenfassung:	To evaluate vascular morphology and density, angiogenic switch activation, vascular endothelial growth factor (VEGF) expression, and endothelial cell (EC) proliferation in the hamster cheek pouch (HCP) model of oral cancer. Immunohistochemical detection of factor VIII, 5'-Bromo-2'-Deoxyuridine (BrdU) and VEGF was performed in pre-malignant and tumoral tissues. Activation of angiogenesis was detected adjacent to epithelial dysplasia. Vascularized area and perimeter (p
ISSN:	1791-7530