The ICAM-1 K469E polymorphism is associated with the risk of coronary artery disease: a meta-analysis

BACKGROUNDThe intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism has been indicated to be correlated with coronary artery disease (CAD) susceptibility, but the results of studies are still debatable. Thus, a meta-analysis was carried out. METHODSDatabases including PubMed, Embase, Web of...

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Veröffentlicht in:	Coronary artery disease 2014-12, Vol.25 (8), p.665-670
Hauptverfasser:	Li, Daolin, Qu, Chunsheng, Dong, Pingshuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Asian Continental Ancestry Group - genetics Chi-Square Distribution Coronary Disease - diagnosis Coronary Disease - ethnology Coronary Disease - genetics European Continental Ancestry Group - genetics Genetic Association Studies Genetic Predisposition to Disease Humans Intercellular Adhesion Molecule-1 - genetics Myocardial Infarction - ethnology Myocardial Infarction - genetics Odds Ratio Phenotype Polymorphism, Genetic Risk Factors
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Zusammenfassung:	BACKGROUNDThe intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism has been indicated to be correlated with coronary artery disease (CAD) susceptibility, but the results of studies are still debatable. Thus, a meta-analysis was carried out. METHODSDatabases including PubMed, Embase, Web of Science, and CNKI were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. RESULTSEighteen studies with 3546 cases and 3852 controls were included in this meta-analysis. The association between the ICAM-1 K469E polymorphism and the risk of CAD was significant (OR=1.77; 95% CI, 1.52–2.05; P
ISSN:	0954-6928 1473-5830
DOI:	10.1097/MCA.0000000000000136