Ipilimumab treatment associated pituitary hypophysitis: Clinical presentation and imaging diagnosis

Highlights • Ipilimumab is an immunomodulating drug used for treatment of metastatic melanoma. • Ipilimumab use may be associated with autoimmune lymphocytic hypophysitis. • Symptoms include headache, fatigue, vision changes, endocrinopathy, hyponatremia. • MRI findings of pituitary gland and stalk...

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Veröffentlicht in:	Clinical neurology and neurosurgery 2014-10, Vol.125, p.125-130
Hauptverfasser:	Chodakiewitz, Yosef, Brown, Sanford, Boxerman, Jerrold L, Brody, Jeffrey M, Rogg, Jeffrey M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anorexia Antibodies, Monoclonal - therapeutic use Autoimmune lymphocytic hypophysitis Clinical trials Diagnostic Imaging Headaches Hormones Humans Hypopituitarism - diagnosis Hypopituitarism - drug therapy Infertility Ipilimumab Magnetic Resonance Imaging - methods Medical treatment Melanoma Melanoma - diagnosis Melanoma - drug therapy Metastasis MRI Neurology Neurosurgery Patients Pituitary Pituitary gland Pituitary Gland - pathology Postpartum period Skin cancer Tumors
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Beschreibung
Zusammenfassung:	Highlights • Ipilimumab is an immunomodulating drug used for treatment of metastatic melanoma. • Ipilimumab use may be associated with autoimmune lymphocytic hypophysitis. • Symptoms include headache, fatigue, vision changes, endocrinopathy, hyponatremia. • MRI findings of pituitary gland and stalk enlargement with homogeneous enhancement. • Concern for ipilimumab hypophysitis is important for early diagnosis and treatment.
ISSN:	0303-8467 1872-6968
DOI:	10.1016/j.clineuro.2014.06.011