Prussian blue nanoparticles for laser-induced photothermal therapy of tumors
We describe Prussian blue nanoparticles (PB NPs) for laser-induced photothermal therapy (PTT) of tumors. The PB NPs exhibit strong absorbance at near infrared (NIR) wavelengths, are stable, non-toxic, and have 20.5% photothermal conversion efficiencies. PTT with PB NPs in a mouse model of neuroblast...
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| Veröffentlicht in: | RSC advances 2014-01, Vol.4 (56), p.29729-29734 |
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| container_issue | 56 |
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| container_title | RSC advances |
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| creator | Hoffman, Hilary A. Chakrabarti, Lina Dumont, Matthieu F. Sandler, Anthony D. Fernandes, Rohan |
| description | We describe Prussian blue nanoparticles (PB NPs) for laser-induced photothermal therapy (PTT) of tumors. The PB NPs exhibit strong absorbance at near infrared (NIR) wavelengths, are stable, non-toxic, and have 20.5% photothermal conversion efficiencies. PTT with PB NPs in a mouse model of neuroblastoma resulted in marked tumor debulking, increased tumor-free days, and decreased tumor growth rates in tumor-bearing mice. These findings demonstrate the clinical potential of PB NPs for PTT of tumors. |
| doi_str_mv | 10.1039/C4RA05209A |
| format | Article |
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The PB NPs exhibit strong absorbance at near infrared (NIR) wavelengths, are stable, non-toxic, and have 20.5% photothermal conversion efficiencies. PTT with PB NPs in a mouse model of neuroblastoma resulted in marked tumor debulking, increased tumor-free days, and decreased tumor growth rates in tumor-bearing mice. These findings demonstrate the clinical potential of PB NPs for PTT of tumors.</description><subject>Infrared</subject><subject>Mathematical models</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Photothermal conversion</subject><subject>Therapy</subject><subject>Tumors</subject><subject>Wavelengths</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpNkE1LxDAURYMoOIyz8RdkKUL15bN2OQzqCAVFdF2S9IWppE1N2sX8e2cYQe_m3MXhLi4h1wzuGIjqfiPf16A4VOszsuAgdcFBV-f_-iVZ5fwFh2jFuGYLUr-lOefODNSGGelghjiaNHUuYKY-JhpMxlR0Qzs7bOm4i1Ocdph6E-iRZtzT6Ok09zHlK3LhTci4-uWSfD49fmy2Rf36_LJZ14UTAqbCS660dqxCkAYYs15Lp1AoWynd2pJzNCUvhedWWW-F9KVR0rWyZcBViWJJbk67Y4rfM-ap6bvsMAQzYJxzwzQHEBrg4aDenlSXYs4JfTOmrjdp3zBojq81f6-JH4REX1U</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Hoffman, Hilary A.</creator><creator>Chakrabarti, Lina</creator><creator>Dumont, Matthieu F.</creator><creator>Sandler, Anthony D.</creator><creator>Fernandes, Rohan</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140101</creationdate><title>Prussian blue nanoparticles for laser-induced photothermal therapy of tumors</title><author>Hoffman, Hilary A. ; Chakrabarti, Lina ; Dumont, Matthieu F. ; Sandler, Anthony D. ; Fernandes, Rohan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-f42566c19e04a011bf64c5e35b956db722ea7273f2b5bfb34f7a54cd4d10257e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Infrared</topic><topic>Mathematical models</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Photothermal conversion</topic><topic>Therapy</topic><topic>Tumors</topic><topic>Wavelengths</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoffman, Hilary A.</creatorcontrib><creatorcontrib>Chakrabarti, Lina</creatorcontrib><creatorcontrib>Dumont, Matthieu F.</creatorcontrib><creatorcontrib>Sandler, Anthony D.</creatorcontrib><creatorcontrib>Fernandes, Rohan</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoffman, Hilary A.</au><au>Chakrabarti, Lina</au><au>Dumont, Matthieu F.</au><au>Sandler, Anthony D.</au><au>Fernandes, Rohan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prussian blue nanoparticles for laser-induced photothermal therapy of tumors</atitle><jtitle>RSC advances</jtitle><date>2014-01-01</date><risdate>2014</risdate><volume>4</volume><issue>56</issue><spage>29729</spage><epage>29734</epage><pages>29729-29734</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>We describe Prussian blue nanoparticles (PB NPs) for laser-induced photothermal therapy (PTT) of tumors. The PB NPs exhibit strong absorbance at near infrared (NIR) wavelengths, are stable, non-toxic, and have 20.5% photothermal conversion efficiencies. PTT with PB NPs in a mouse model of neuroblastoma resulted in marked tumor debulking, increased tumor-free days, and decreased tumor growth rates in tumor-bearing mice. These findings demonstrate the clinical potential of PB NPs for PTT of tumors.</abstract><doi>10.1039/C4RA05209A</doi><tpages>6</tpages></addata></record> |
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| ispartof | RSC advances, 2014-01, Vol.4 (56), p.29729-29734 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Infrared Mathematical models Mice Nanoparticles Photothermal conversion Therapy Tumors Wavelengths |
| title | Prussian blue nanoparticles for laser-induced photothermal therapy of tumors |
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