Prussian blue nanoparticles for laser-induced photothermal therapy of tumors

Prussian blue nanoparticles for laser-induced photothermal therapy of tumors

We describe Prussian blue nanoparticles (PB NPs) for laser-induced photothermal therapy (PTT) of tumors. The PB NPs exhibit strong absorbance at near infrared (NIR) wavelengths, are stable, non-toxic, and have 20.5% photothermal conversion efficiencies. PTT with PB NPs in a mouse model of neuroblast...

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Veröffentlicht in:RSC advances 2014-01, Vol.4 (56), p.29729-29734
Hauptverfasser: Hoffman, Hilary A., Chakrabarti, Lina, Dumont, Matthieu F., Sandler, Anthony D., Fernandes, Rohan
Format: Artikel
Sprache:eng
Schlagworte:
Infrared
Mathematical models
Mice
Nanoparticles
Photothermal conversion
Therapy
Tumors
Wavelengths
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Zusammenfassung:We describe Prussian blue nanoparticles (PB NPs) for laser-induced photothermal therapy (PTT) of tumors. The PB NPs exhibit strong absorbance at near infrared (NIR) wavelengths, are stable, non-toxic, and have 20.5% photothermal conversion efficiencies. PTT with PB NPs in a mouse model of neuroblastoma resulted in marked tumor debulking, increased tumor-free days, and decreased tumor growth rates in tumor-bearing mice. These findings demonstrate the clinical potential of PB NPs for PTT of tumors.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA05209A