Urokinase versus VATS for treatment of empyema: a randomized multicenter clinical trial

Parapneumonic empyema (PPE) is a frequent complication of acute bacterial pneumonia in children. There is limited evidence regarding the optimal treatment of this condition. The aim of this study was to compare the efficacy of drainage plus urokinase versus video-assisted thoracoscopic surgery in th...

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Veröffentlicht in:	Pediatrics (Evanston) 2014-11, Vol.134 (5), p.e1301-e1307
Hauptverfasser:	Marhuenda, Claudia, Barceló, Concepció, Fuentes, Inmaculada, Guillén, Gabriela, Cano, Indalecio, López, María, Hernández, Francisco, Pérez-Yarza, Eduardo G, Matute, José A, García-Casillas, María A, Alvarez, Víctor, Moreno-Galdó, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Care and treatment Child Child, Preschool Children Children & youth Clinical trials Comparative analysis Dosage and administration Empyema Empyema, Pleural - diagnosis Empyema, Pleural - drug therapy Empyema, Pleural - surgery Female Health aspects Humans Infant Male Medical treatment Pediatrics Pilot Projects Pneumonia Prospective Studies Thoracic Surgery, Video-Assisted - methods Thoracoscopy Urokinase Urokinase-Type Plasminogen Activator - therapeutic use
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Zusammenfassung:	Parapneumonic empyema (PPE) is a frequent complication of acute bacterial pneumonia in children. There is limited evidence regarding the optimal treatment of this condition. The aim of this study was to compare the efficacy of drainage plus urokinase versus video-assisted thoracoscopic surgery in the treatment of PPE in childhood. This prospective, randomized, multicenter clinical trial enrolled patients aged
ISSN:	0031-4005 1098-4275
DOI:	10.1542/peds.2013-3935