A Controlled Trial of Plasmapheresis Therapy in Severe Lupus Nephritis

A Controlled Trial of Plasmapheresis Therapy in Severe Lupus Nephritis

THE mortality rate in patients with systemic lupus erythematosus and severe glomerulonephritis (lupus nephritis) is high. 1 2 3 In 1976 plasmapheresis was proposed as a new approach to interrupting the pathogenetic events in systemic lupus erythematosus. 4 The initial use of plasmapheresis in system...

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Veröffentlicht in:The New England journal of medicine 1992-05, Vol.326 (21), p.1373-1379
Hauptverfasser: Lewis, Edmund J, Hunsicker, Lawrence G, Lan, Shu-Ping, Rohde, Richard D, Lachin, John M
Format: Artikel
Sprache:eng
Schlagworte:
Autoimmune diseases
Biological and medical sciences
Biopsy
Creatinine
Cryoglobulins
Cyclophosphamide
Deoxyribonucleic acid
DNA
Excretion
Glomerulonephritis
Immunosuppressive agents
Kidneys
Lupus
Lupus nephritis
Medical sciences
Mortality
Nephritis
Nephrology. Urinary tract diseases
Patients
Plasmapheresis
Prednisone
Renal failure
Systemic lupus erythematosus
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Zusammenfassung:THE mortality rate in patients with systemic lupus erythematosus and severe glomerulonephritis (lupus nephritis) is high. 1 2 3 In 1976 plasmapheresis was proposed as a new approach to interrupting the pathogenetic events in systemic lupus erythematosus. 4 The initial use of plasmapheresis in systemic lupus erythematosus resulted in several reports of improvement, 4 5 6 7 8 but the studies were uncontrolled. We report the results of a controlled clinical trial of plasmapheresis in the treatment of patients with severe lupus nephritis. Methods The Lupus Nephritis Collaborative Study was organized to assess the efficacy and safety of plasmapheresis for the treatment of patients with severe lupus nephritis. Study . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199205213262101