Inactivation of macrophage nitric oxide synthase activity by N super(G)-methyl-L-arginine

Inactivation of macrophage nitric oxide synthase activity by N super(G)-methyl-L-arginine

Initial rate kinetics were performed with a spectrophotometric assay based on the oxidation of oxy- to methemoglobin by multiplied by N = O. N super(G)-Methyl-L-arginine was a competitive inhibitor of multiplied by N = O synthase activity. The data indicate that N super(G)-methyl-L-arginine acts as...

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Veröffentlicht in:Biochemical and biophysical research communications 1991-01, Vol.177 (2), p.828-833
Hauptverfasser: Olken, N M, Rusche, K M, Richards, M K, Marletta, MA
Format: Artikel
Sprache:eng
Schlagworte:
activity
inactivation
macrophages
N super(G)-methyl-L-arginine
nitric oxide synthase
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Zusammenfassung:Initial rate kinetics were performed with a spectrophotometric assay based on the oxidation of oxy- to methemoglobin by multiplied by N = O. N super(G)-Methyl-L-arginine was a competitive inhibitor of multiplied by N = O synthase activity. The data indicate that N super(G)-methyl-L-arginine acts as a mechanism-based enzyme inactivator of murine macrophage multiplied by N = O synthase.
ISSN:0006-291X