EFFECTIVE TREATMENT OF SEVERE BK VIRUS-ASSOCIATED HEMORRHAGIC CYSTITIS WITH LEFLUNOMIDE IN CHILDREN AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: A PILOT STUDY

Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatme...

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Veröffentlicht in:	The Pediatric infectious disease journal 2014-11, Vol.33 (11), p.1193-1195
Hauptverfasser:	WU, Kang-Hsi, TEFU WENG, WU, Han-Ping, PENG, Ching-Tien, SHEU, Ji-Nan, CHAO, Yu-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences BK Virus Bone marrow, stem cells transplantation. Graft versus host reaction Child Cystitis - drug therapy Cystitis - virology Female Hematopoietic Stem Cell Transplantation - adverse effects Hematuria - drug therapy Hematuria - virology Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Infectious diseases Isoxazoles - adverse effects Isoxazoles - therapeutic use Male Medical sciences Nephrology. Urinary tract diseases Pilot Projects Polyomavirus Infections Prospective Studies Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor Virus Infections Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Viral diseases Viral Load
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Zusammenfassung:	Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0000000000000407