Efficacy and Safety of Darunavir/Ritonavir at 48 Weeks in Treatment-naïve, HIV-1-infected Adolescents: Results From a Phase 2 Open-label Trial (DIONE)

Efficacy and Safety of Darunavir/Ritonavir at 48 Weeks in Treatment-naïve, HIV-1-infected Adolescents: Results From a Phase 2 Open-label Trial (DIONE)

Twice-daily darunavir/ritonavir is indicated in treatment-experienced children (≥3 years). This study assessed once-daily administration in treatment-naïve adolescents. Phase 2, 48-week, open-label, single-arm study evaluating pharmacokinetics, safety and efficacy of once-daily darunavir/ritonavir 8...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Pediatric infectious disease journal 2014-09, Vol.33 (9), p.940-945
Hauptverfasser: FLYNN, Patricia, KOMAR, Svitlana, BLANCHE, Stephane, GIAQUINTO, Carlo, NOGUERA-JULIAN, Antoni, WELCH, Steven, LATHOUWERS, Erkki, VAN DE CASTEELE, Tom, KAKUDA, Thomas N, OPSOMER, Magda
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Anemia - chemically induced
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
Darunavir
Dideoxynucleosides - therapeutic use
Drug Resistance, Viral
Drug Therapy, Combination
Female
HIV Infections - drug therapy
HIV Infections - immunology
HIV Protease Inhibitors - pharmacokinetics
HIV Protease Inhibitors - therapeutic use
HIV-1
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Lamivudine - therapeutic use
Male
Medical sciences
Medication Adherence
Nausea - chemically induced
Neutropenia - chemically induced
Pharmacology. Drug treatments
Reverse Transcriptase Inhibitors - therapeutic use
Ritonavir - pharmacokinetics
Ritonavir - therapeutic use
Sulfonamides - pharmacokinetics
Sulfonamides - therapeutic use
Time Factors
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load - drug effects
Vomiting - chemically induced
Zidovudine - therapeutic use
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Twice-daily darunavir/ritonavir is indicated in treatment-experienced children (≥3 years). This study assessed once-daily administration in treatment-naïve adolescents. Phase 2, 48-week, open-label, single-arm study evaluating pharmacokinetics, safety and efficacy of once-daily darunavir/ritonavir 800/100 mg in treatment-naïve, HIV-1-infected adolescents (≥12 to
ISSN:0891-3668
1532-0987
DOI:10.1097/INF.0000000000000308