Electrophysiological and flow cytometric studies on mechanism of gentamicin nephrotoxicity in cultured renal cells

Electrophysiological and flow cytometric studies on mechanism of gentamicin nephrotoxicity in cultured renal cells

The present study concerns investigation of gentamicin nephrotoxicity in established renal cells. Aminoglycosides including gentamicin exhibit significant nephrotoxicity. Established renal cells provide useful models for study of renal pharmacology and toxicology. In this investigation we have used...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: McGlynn, H, Healy, N, Ryan, M P
Format: Tagungsbericht
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator McGlynn, H
Healy, N
Ryan, M P
description The present study concerns investigation of gentamicin nephrotoxicity in established renal cells. Aminoglycosides including gentamicin exhibit significant nephrotoxicity. Established renal cells provide useful models for study of renal pharmacology and toxicology. In this investigation we have used the established renal cell lines, LLC-PK sub(1) (of proximal tubular origin) and MDCK (of distal tubular and collecting duct origin). We have used biochemical, electrophysiological and flow cytometric techniques in the investigation of effects of gentamicin on these two cell types.
format Conference Proceeding
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_16183137</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16183137</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_161831373</originalsourceid><addsrcrecordid>eNqNjEFuwjAQRb0AqQF6h1l1hxRjCHRdBfUA3SPLmSRGtif1jEVz-wapB-jq6z09_ZWqanOs96dzo1_Uhvle1_pweTeVym1AJ5mmcWZPgQbvbACbOugDPcDNQhElewcspfPIQAkiutEmzxGohwGT2OidT5BwGjMJ_SwkMyzGlSAlYwcZ0_LrMATeqXVvA-Pr327V27X9-vjcT5m-C7LcoudnaRNS4Ztu9MVoczb_Dn8BDjNP9Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype><pqid>16183137</pqid></control><display><type>conference_proceeding</type><title>Electrophysiological and flow cytometric studies on mechanism of gentamicin nephrotoxicity in cultured renal cells</title><source>SpringerLink Journals</source><creator>McGlynn, H ; Healy, N ; Ryan, M P</creator><contributor>de Wolff, FA ; Bolt, HM ; Henderson, PT (eds)</contributor><creatorcontrib>McGlynn, H ; Healy, N ; Ryan, M P ; de Wolff, FA ; Bolt, HM ; Henderson, PT (eds)</creatorcontrib><description>The present study concerns investigation of gentamicin nephrotoxicity in established renal cells. Aminoglycosides including gentamicin exhibit significant nephrotoxicity. Established renal cells provide useful models for study of renal pharmacology and toxicology. In this investigation we have used the established renal cell lines, LLC-PK sub(1) (of proximal tubular origin) and MDCK (of distal tubular and collecting duct origin). We have used biochemical, electrophysiological and flow cytometric techniques in the investigation of effects of gentamicin on these two cell types.</description><identifier>ISSN: 0340-5761</identifier><language>eng</language><ispartof>Archives of toxicology, 1992</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,776,780,785,786,23911,23912,25120</link.rule.ids></links><search><contributor>de Wolff, FA</contributor><contributor>Bolt, HM</contributor><contributor>Henderson, PT (eds)</contributor><creatorcontrib>McGlynn, H</creatorcontrib><creatorcontrib>Healy, N</creatorcontrib><creatorcontrib>Ryan, M P</creatorcontrib><title>Electrophysiological and flow cytometric studies on mechanism of gentamicin nephrotoxicity in cultured renal cells</title><title>Archives of toxicology</title><description>The present study concerns investigation of gentamicin nephrotoxicity in established renal cells. Aminoglycosides including gentamicin exhibit significant nephrotoxicity. Established renal cells provide useful models for study of renal pharmacology and toxicology. In this investigation we have used the established renal cell lines, LLC-PK sub(1) (of proximal tubular origin) and MDCK (of distal tubular and collecting duct origin). We have used biochemical, electrophysiological and flow cytometric techniques in the investigation of effects of gentamicin on these two cell types.</description><issn>0340-5761</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>1992</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNqNjEFuwjAQRb0AqQF6h1l1hxRjCHRdBfUA3SPLmSRGtif1jEVz-wapB-jq6z09_ZWqanOs96dzo1_Uhvle1_pweTeVym1AJ5mmcWZPgQbvbACbOugDPcDNQhElewcspfPIQAkiutEmzxGohwGT2OidT5BwGjMJ_SwkMyzGlSAlYwcZ0_LrMATeqXVvA-Pr327V27X9-vjcT5m-C7LcoudnaRNS4Ztu9MVoczb_Dn8BDjNP9Q</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>McGlynn, H</creator><creator>Healy, N</creator><creator>Ryan, M P</creator><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19920101</creationdate><title>Electrophysiological and flow cytometric studies on mechanism of gentamicin nephrotoxicity in cultured renal cells</title><author>McGlynn, H ; Healy, N ; Ryan, M P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_161831373</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>1992</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McGlynn, H</creatorcontrib><creatorcontrib>Healy, N</creatorcontrib><creatorcontrib>Ryan, M P</creatorcontrib><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McGlynn, H</au><au>Healy, N</au><au>Ryan, M P</au><au>de Wolff, FA</au><au>Bolt, HM</au><au>Henderson, PT (eds)</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Electrophysiological and flow cytometric studies on mechanism of gentamicin nephrotoxicity in cultured renal cells</atitle><btitle>Archives of toxicology</btitle><date>1992-01-01</date><risdate>1992</risdate><issn>0340-5761</issn><abstract>The present study concerns investigation of gentamicin nephrotoxicity in established renal cells. Aminoglycosides including gentamicin exhibit significant nephrotoxicity. Established renal cells provide useful models for study of renal pharmacology and toxicology. In this investigation we have used the established renal cell lines, LLC-PK sub(1) (of proximal tubular origin) and MDCK (of distal tubular and collecting duct origin). We have used biochemical, electrophysiological and flow cytometric techniques in the investigation of effects of gentamicin on these two cell types.</abstract></addata></record>
fulltext fulltext
identifier ISSN: 0340-5761
ispartof Archives of toxicology, 1992
issn 0340-5761
language eng
recordid cdi_proquest_miscellaneous_16183137
source SpringerLink Journals
title Electrophysiological and flow cytometric studies on mechanism of gentamicin nephrotoxicity in cultured renal cells
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T05%3A09%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=proceeding&rft.atitle=Electrophysiological%20and%20flow%20cytometric%20studies%20on%20mechanism%20of%20gentamicin%20nephrotoxicity%20in%20cultured%20renal%20cells&rft.btitle=Archives%20of%20toxicology&rft.au=McGlynn,%20H&rft.date=1992-01-01&rft.issn=0340-5761&rft_id=info:doi/&rft_dat=%3Cproquest%3E16183137%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16183137&rft_id=info:pmid/&rfr_iscdi=true