α-Glucosidase Inhibitors from the Stems of Embelia ribes

From the ethyl acetate extract of the stems of Embelia ribes (Myrsinaceae), a new alkenylresorcinol, embeliphenol A (1), together with 11 known compounds have been isolated. Their structures were elucidated on the basis of spectroscopic data. All compounds possessed significant α‐glucosidase inhibit...

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Veröffentlicht in:	Phytotherapy research 2014-11, Vol.28 (11), p.1632-1636
Hauptverfasser:	Dang, Phu Hoang, Nguyen, Hai Xuan, Nguyen, Nhan Trung, Le, Hanh Ngoc Thi, Nguyen, Mai Thanh Thi
Format:	Artikel
Sprache:	eng
Schlagworte:	Embelia - chemistry Embelia ribes embeliphenol A Glycoside Hydrolase Inhibitors - chemistry Glycoside Hydrolase Inhibitors - isolation & purification Molecular Structure Plant Extracts - chemistry Plant Stems - chemistry Resorcinols - chemistry Resorcinols - isolation & purification α-glucosidase inhibition
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Beschreibung
Zusammenfassung:	From the ethyl acetate extract of the stems of Embelia ribes (Myrsinaceae), a new alkenylresorcinol, embeliphenol A (1), together with 11 known compounds have been isolated. Their structures were elucidated on the basis of spectroscopic data. All compounds possessed significant α‐glucosidase inhibitory activity in a concentration‐dependent manner, except for 2 and 9. Compounds 1, 3–6, 8, and 12 showed more potent inhibitory activity, with IC50 values ranging from 10.4 to 116.7 μM, than that of a positive control acarbose (IC50, 214.5 μM). Copyright © 2014 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.5175