The panoply of αβT cells in the skin

Highlights • Most skin αβT cells are skin-tropic resident memory cells. • CD8 T cells reside in epidermis. • CD4 T cells and regulatory T cells reside in dermis. • Features of skin αβT cell-subsets are reviewed. • Harnessing immune system is becoming a promising approach to treat melanoma....

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Veröffentlicht in:	Journal of dermatological science 2014-10, Vol.76 (1), p.3-9
Hauptverfasser:	Nomura, Takashi, Kabashima, Kenji, Miyachi, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4T cells CD8-Positive T-Lymphocytes - immunology CD8T cells Cell Differentiation Cell Membrane - metabolism Cytokines - metabolism Dermatitis, Atopic - immunology Dermatology Drug Eruptions - immunology Forkhead Transcription Factors - metabolism Humans Hypersensitivity Innate-like T cells Interleukin-10 - metabolism Interleukin-17 - immunology Keratinocytes - cytology Killer Cells, Natural - immunology Lichen Planus - immunology Memory T cells Mice Phenotype Regulatory T cells Skin - immunology Skin - pathology Skin T cells T-Lymphocytes - cytology T-Lymphocytes, Helper-Inducer - immunology Th1 Cells - immunology Th2 Cells - immunology Transforming Growth Factor beta - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Most skin αβT cells are skin-tropic resident memory cells. • CD8 T cells reside in epidermis. • CD4 T cells and regulatory T cells reside in dermis. • Features of skin αβT cell-subsets are reviewed. • Harnessing immune system is becoming a promising approach to treat melanoma.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2014.07.010