High Usage of Topical Fusidic Acid and Rapid Clonal Expansion of Fusidic Acid–Resistant Staphylococcus aureus: A Cautionary Tale

Our aim was to assess national prescribing trends and determine longitudinal resistance patterns for topical antimicrobials in New Zealand. We observed a dramatic increase in fusidic acid (FA) resistance, and clonal expansion of FA-resistant Staphylococcus aureus. This increase was concurrent with a...

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Veröffentlicht in:	Clinical infectious diseases 2014-11, Vol.59 (10), p.1451-1454
Hauptverfasser:	Williamson, Deborah A., Monecke, Stefan, Heffernan, Helen, Ritchie, Stephen R., Roberts, Sally A., Upton, Arlo, Thomas, Mark G., Fraser, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Age Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Antimicrobials Bacterial diseases Biological and medical sciences BRIEF REPORT Drug prescriptions Drug Prescriptions - statistics & numerical data Drug resistance Drug Resistance, Bacterial Environmental sciences Fusidic Acid - administration & dosage Fusidic Acid - therapeutic use Human bacterial diseases Humans Infectious diseases Medical sciences Methicillin resistant staphylococcus aureus New Zealand Pharmacology. Drug treatments Prescriptions Registered nurses Resistance mechanisms Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus infections Transdermal medication
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Zusammenfassung:	Our aim was to assess national prescribing trends and determine longitudinal resistance patterns for topical antimicrobials in New Zealand. We observed a dramatic increase in fusidic acid (FA) resistance, and clonal expansion of FA-resistant Staphylococcus aureus. This increase was concurrent with a significant national increase in topical FA dispensing.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciu658