Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations
The enzyme inducing potency of single doses of three 2,3,7,8-substituted mixed halogenated dibenzo- p-dioxins was investigated and compared with 2,3,7,8-TCDD and 2,3,7,8-TBDD. All substances showed a quite similar potency for EROD induction. The use of a substrate concentration of 0.5 μM ethoxyresor...
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| Veröffentlicht in: | Chemosphere (Oxford) 1991, Vol.23 (11), p.1925-1931 |
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| container_end_page | 1931 |
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| container_issue | 11 |
| container_start_page | 1925 |
| container_title | Chemosphere (Oxford) |
| container_volume | 23 |
| creator | Schulz-Schalge, Thomas Koch, Elisabeth Schwind, Karl-Heinz Hutzinger, Otto Neubert, Diether |
| description | The enzyme inducing potency of single doses of three 2,3,7,8-substituted mixed halogenated dibenzo-
p-dioxins was investigated and compared with 2,3,7,8-TCDD and 2,3,7,8-TBDD. All substances showed a quite similar potency for EROD induction. The use of a substrate concentration of 0.5 μM ethoxyresorufin is strongly recommended. |
| doi_str_mv | 10.1016/0045-6535(91)90040-K |
| format | Article |
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p-dioxins was investigated and compared with 2,3,7,8-TCDD and 2,3,7,8-TBDD. All substances showed a quite similar potency for EROD induction. The use of a substrate concentration of 0.5 μM ethoxyresorufin is strongly recommended.</description><subject>2,3,7,8-Tetrabromodibenzo- p-dioxin</subject><subject>2,3,7,8-Tetrachlorodibenzo- p-dioxin</subject><subject>2,3,7-Tribromo-8-chlorodibenzo- p-dioxin</subject><subject>2,3-Dibromo-7,8-dichlorodibenzo- p-dioxin</subject><subject>2-Bromo-3,7,8-trichlorodibenzo- p-dioxin</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Enzyme induction</subject><subject>Ethoxyresorufin O-deethylase, Wistar rats</subject><subject>Medical sciences</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNp9kc1uGyEUhVHUSnHTvkEWLKqqkTwpzAAzbCq1dv6USN24a4ThTkIyAy7gKM4r9KXD1FGWXQG63zlX54DQMSWnlFDxjRDGK8Eb_lXSE1lepLo-QDPatbKitezeodkbcog-pHRPSNFxOUN_r7zdmuweAW9CBm92OPR4tVgu53j1c7nE2luc7yIArufNvJ131eiewFZ3egi34HUGi60LT84n7DweilPEozMxpDBCmtxGPQCOOqdTfOafdyPgB-chO4NN8MlZKDNXbh_R-14PCT69nkfo9_nZanFZ3fy6uFr8uKlM07JcaUGssYQL2jEDDWE9Z6bTppNU1GvBqSWaSdkyaNbQ1RKEhnUrmGZrWXegmyP0Ze-7ieHPFlJWo0sGhkF7CNukqKCc87YtINuDU5oUoVeb6EYdd4oSNTWvplrVVKuSVP1rXl0X2edXf52MHvqovXHpTctYw0QtCvZ9j0HJ-uggqmRc-QGwLoLJygb3_z0vKumXaA</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Schulz-Schalge, Thomas</creator><creator>Koch, Elisabeth</creator><creator>Schwind, Karl-Heinz</creator><creator>Hutzinger, Otto</creator><creator>Neubert, Diether</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1991</creationdate><title>Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations</title><author>Schulz-Schalge, Thomas ; Koch, Elisabeth ; Schwind, Karl-Heinz ; Hutzinger, Otto ; Neubert, Diether</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-a60dcd056184ce304f54c8ac89162b651d0a49974e3be829e6aeb764a4b928ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>2,3,7,8-Tetrabromodibenzo- p-dioxin</topic><topic>2,3,7,8-Tetrachlorodibenzo- p-dioxin</topic><topic>2,3,7-Tribromo-8-chlorodibenzo- p-dioxin</topic><topic>2,3-Dibromo-7,8-dichlorodibenzo- p-dioxin</topic><topic>2-Bromo-3,7,8-trichlorodibenzo- p-dioxin</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Enzyme induction</topic><topic>Ethoxyresorufin O-deethylase, Wistar rats</topic><topic>Medical sciences</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schulz-Schalge, Thomas</creatorcontrib><creatorcontrib>Koch, Elisabeth</creatorcontrib><creatorcontrib>Schwind, Karl-Heinz</creatorcontrib><creatorcontrib>Hutzinger, Otto</creatorcontrib><creatorcontrib>Neubert, Diether</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schulz-Schalge, Thomas</au><au>Koch, Elisabeth</au><au>Schwind, Karl-Heinz</au><au>Hutzinger, Otto</au><au>Neubert, Diether</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations</atitle><jtitle>Chemosphere (Oxford)</jtitle><date>1991</date><risdate>1991</risdate><volume>23</volume><issue>11</issue><spage>1925</spage><epage>1931</epage><pages>1925-1931</pages><issn>0045-6535</issn><eissn>1879-1298</eissn><coden>CMSHAF</coden><abstract>The enzyme inducing potency of single doses of three 2,3,7,8-substituted mixed halogenated dibenzo-
p-dioxins was investigated and compared with 2,3,7,8-TCDD and 2,3,7,8-TBDD. All substances showed a quite similar potency for EROD induction. The use of a substrate concentration of 0.5 μM ethoxyresorufin is strongly recommended.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/0045-6535(91)90040-K</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0045-6535 |
| ispartof | Chemosphere (Oxford), 1991, Vol.23 (11), p.1925-1931 |
| issn | 0045-6535 1879-1298 |
| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | 2,3,7,8-Tetrabromodibenzo- p-dioxin 2,3,7,8-Tetrachlorodibenzo- p-dioxin 2,3,7-Tribromo-8-chlorodibenzo- p-dioxin 2,3-Dibromo-7,8-dichlorodibenzo- p-dioxin 2-Bromo-3,7,8-trichlorodibenzo- p-dioxin Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Enzyme induction Ethoxyresorufin O-deethylase, Wistar rats Medical sciences Toxicology Various organic compounds |
| title | Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations |
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