Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations

The enzyme inducing potency of single doses of three 2,3,7,8-substituted mixed halogenated dibenzo- p-dioxins was investigated and compared with 2,3,7,8-TCDD and 2,3,7,8-TBDD. All substances showed a quite similar potency for EROD induction. The use of a substrate concentration of 0.5 μM ethoxyresor...

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Veröffentlicht in:	Chemosphere (Oxford) 1991, Vol.23 (11), p.1925-1931
Hauptverfasser:	Schulz-Schalge, Thomas, Koch, Elisabeth, Schwind, Karl-Heinz, Hutzinger, Otto, Neubert, Diether
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8-Tetrabromodibenzo- p-dioxin 2,3,7,8-Tetrachlorodibenzo- p-dioxin 2,3,7-Tribromo-8-chlorodibenzo- p-dioxin 2,3-Dibromo-7,8-dichlorodibenzo- p-dioxin 2-Bromo-3,7,8-trichlorodibenzo- p-dioxin Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Enzyme induction Ethoxyresorufin O-deethylase, Wistar rats Medical sciences Toxicology Various organic compounds
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Zusammenfassung:	The enzyme inducing potency of single doses of three 2,3,7,8-substituted mixed halogenated dibenzo- p-dioxins was investigated and compared with 2,3,7,8-TCDD and 2,3,7,8-TBDD. All substances showed a quite similar potency for EROD induction. The use of a substrate concentration of 0.5 μM ethoxyresorufin is strongly recommended.
ISSN:	0045-6535 1879-1298
DOI:	10.1016/0045-6535(91)90040-K