Sister chromatid exchanges and chromosome aberrations in lymphocytes of nurses handling antineoplastic drugs

Chromosomal aberrations (CA) and sister‐chromatid exchanges (SCE) were investigated in peripheral lymphocytes of 15 nurses and nurse's aides handling cytostatic agents in hospital oncology units. Significantly increased frequencies were noted for both CA and SCE rates when the exposed individua...

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Veröffentlicht in:	International journal of cancer 1992-02, Vol.50 (3), p.341-344
Hauptverfasser:	Goloni‐Bertollo, Eny Maria, Tajara, Eloiza Helena, Manzato, Antonio José, Varella‐Garcia, Marileila
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Agents - adverse effects Biological and medical sciences Chromosome Aberrations Drug toxicity and drugs side effects treatment Female Humans Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Nurses Nursing Assistants Occupational Exposure Pharmacology. Drug treatments Sister Chromatid Exchange
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Zusammenfassung:	Chromosomal aberrations (CA) and sister‐chromatid exchanges (SCE) were investigated in peripheral lymphocytes of 15 nurses and nurse's aides handling cytostatic agents in hospital oncology units. Significantly increased frequencies were noted for both CA and SCE rates when the exposed individuals were compared with 15 nurses working in other hospital units and to a control sample matched by sex and age. This points to the need for emphasizing protective measures in the handling of anti‐neoplastic agents.
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.2910500302