The metabolism of 2-methylheptane in male Fischer 344 rats
The urinary metabolites of 2-methylheptane (2-MH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 2-methyl-1,2-heptanediol, 2-methyl-1,5-heptanediol, 2-methyl-2,5-heptanediol, 2-methylheptanoic acid and 2-methyl-5-hydroxy-1-heptanoic acid. Metabolism strongly favored the f...
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| Veröffentlicht in: | Chemosphere (Oxford) 1992, Vol.24 (5), p.517-524 |
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| container_title | Chemosphere (Oxford) |
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| creator | Serve, M.Paul Bombick, D.D. Clemens, J.Matthew McDonald, Gayle A. Mattie, David R. |
| description | The urinary metabolites of 2-methylheptane (2-MH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 2-methyl-1,2-heptanediol, 2-methyl-1,5-heptanediol, 2-methyl-2,5-heptanediol, 2-methylheptanoic acid and 2-methyl-5-hydroxy-1-heptanoic acid. Metabolism strongly favored the formation of diols. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Histopathologic examination of the kidneys revealed minimal hyaline droplet formation (α2u-globulin nephropathy) in the proximal tubule area. |
| doi_str_mv | 10.1016/0045-6535(92)90208-9 |
| format | Article |
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Metabolism strongly favored the formation of diols. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). 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| subjects | Air Biological and medical sciences Environmental pollutants toxicology Medical sciences Toxicology |
| title | The metabolism of 2-methylheptane in male Fischer 344 rats |
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