The metabolism of 2-methylheptane in male Fischer 344 rats

The urinary metabolites of 2-methylheptane (2-MH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 2-methyl-1,2-heptanediol, 2-methyl-1,5-heptanediol, 2-methyl-2,5-heptanediol, 2-methylheptanoic acid and 2-methyl-5-hydroxy-1-heptanoic acid. Metabolism strongly favored the f...

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Veröffentlicht in:	Chemosphere (Oxford) 1992, Vol.24 (5), p.517-524
Hauptverfasser:	Serve, M.Paul, Bombick, D.D., Clemens, J.Matthew, McDonald, Gayle A., Mattie, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Biological and medical sciences Environmental pollutants toxicology Medical sciences Toxicology
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Zusammenfassung:	The urinary metabolites of 2-methylheptane (2-MH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 2-methyl-1,2-heptanediol, 2-methyl-1,5-heptanediol, 2-methyl-2,5-heptanediol, 2-methylheptanoic acid and 2-methyl-5-hydroxy-1-heptanoic acid. Metabolism strongly favored the formation of diols. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Histopathologic examination of the kidneys revealed minimal hyaline droplet formation (α2u-globulin nephropathy) in the proximal tubule area.
ISSN:	0045-6535 1879-1298
DOI:	10.1016/0045-6535(92)90208-9