Is there a role for cyclosporine in asthma?

CsA, as discussed in this review, affects inflammatory cells and their mediators. Its effects appear to exceed those effects induced by other anti-inflammatory agents and suggest its probable usefulness in the management of severe steroid-dependent asthma. Mechanisms of the action of CsA have been r...

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Veröffentlicht in:	Journal of allergy and clinical immunology 1992-02, Vol.89 (2), p.629-636
Hauptverfasser:	Calderón, Eduardo, Lockey, Richard F., Bukantz, Samuel C., Coffey, Ronald G., Ledford, Dennis K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma - drug therapy Asthma - etiology Asthma - physiopathology Biological and medical sciences Cyclosporine - adverse effects Cyclosporine - pharmacokinetics Cyclosporine - pharmacology Cyclosporine - therapeutic use Depression, Chemical Dose-Response Relationship, Drug Humans Immunomodulators Medical sciences Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	CsA, as discussed in this review, affects inflammatory cells and their mediators. Its effects appear to exceed those effects induced by other anti-inflammatory agents and suggest its probable usefulness in the management of severe steroid-dependent asthma. Mechanisms of the action of CsA have been reviewed with that objective in mind.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/0091-6749(92)90331-U