Specific thalamic nuclei function as novel ‘nociceptive discriminators’ in the endogenous control of nociception in rats

Highlights ► Descending controls differ in the modulation of peripheral nociceptive afferents. ► Thalamic MD and VM nuclei discriminate mechanically and heat mediated nociception. ► Thalamic MD nucleus facilitates mechanically evoked nociception. ► Heat-evoked nociception is inhibited by thalamic VM...

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Veröffentlicht in:	Neuroscience 2013-03, Vol.232, p.53-63
Hauptverfasser:	You, H.-J, Lei, J, Niu, N, Yang, L, Fan, X.-L, Tjølsen, A, Li, Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences endogenous descending controls Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Hot Temperature hyperalgesia Hyperalgesia - physiopathology hypoalgesia Male Medical sciences Motor Activity - physiology Muscle, Skeletal - physiopathology Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Nociception - physiology pain Pain Threshold - physiology Random Allocation Rats, Sprague-Dawley Saline Solution, Hypertonic Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Thalamic Nuclei - physiopathology thalamus Touch Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► Descending controls differ in the modulation of peripheral nociceptive afferents. ► Thalamic MD and VM nuclei discriminate mechanically and heat mediated nociception. ► Thalamic MD nucleus facilitates mechanically evoked nociception. ► Heat-evoked nociception is inhibited by thalamic VM nucleus.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.12.021