Mechanistic Investigation of Dirhodium-Catalyzed Intramolecular Allylic C–H Amination versus Alkene Aziridination

The reaction mechanisms and chemoselectivity on the intramolecular allylic C–H amination versus alkene aziridination of 4-pentenylsulfamate promoted by four elaborately selected dirhodium paddlewheel complexes are investigated by a DFT approach. A predominant singlet concerted, highly asynchronous p...

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Veröffentlicht in:Journal of organic chemistry 2014-10, Vol.79 (20), p.9799-9811
Hauptverfasser: Zhang, Xuepeng, Xu, Huiying, Zhao, Cunyuan
Format: Artikel
Sprache:eng
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Zusammenfassung:The reaction mechanisms and chemoselectivity on the intramolecular allylic C–H amination versus alkene aziridination of 4-pentenylsulfamate promoted by four elaborately selected dirhodium paddlewheel complexes are investigated by a DFT approach. A predominant singlet concerted, highly asynchronous pathway and an alternative triplet stepwise pathway are obtained in either C–H amination or alkene aziridination reactions when mediated by weak electron-donating catalysts. A singlet stepwise C–H amination pathway is obtained under strongly donating catalysts. The rate-determining step in the C–H amination is the H-abstraction process. The subsequent diradical-rebound C–N formation in the triplet pathway or the combination of the allylic carbocation and the negative changed N center in the singlet pathway require an identical energy barrier. A mixed singlet–triplet pathway is preferred in either the C–H insertion or alkene aziridination in the Rh2(NCH3CHO)4 entry that the triplet pathway is initially favorable in the rate-determining steps, and the resultant triplet intermediates would convert to a singlet reaction coordinate. The nature of C–H amination or alkene aziridination is estimated to be a stepwise process. The theoretical observations presented in the paper are consistent with the experimental results and, more importantly, provide a thorough understanding of the nature of the reaction mechanisms and the minimum-energy crossing points.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo5019987