Oesophageal function assessed by high-resolution manometry in patients with diabetes and inadequate glycaemic control

Aims To describe oesophageal function in people with diabetes and poor glycaemic control using oesophageal high‐resolution manometry and to compare the result between control subjects and patients with gastro‐oesophageal reflux disease. Methods The results of oesophageal high‐resolution manometry and a gastric emptying test were reviewed in 20 patients with diabetes. The high‐resolution manometry protocol consisted of 5‐ml swallows of water and multiple swallows of water. Oesophageal motility disorders were classified according to the Chicago classification system. The occurence of multiphasic contractions and intragastric and intrabolus pressures were measured. High‐resolution manometry results were compared between 10 control subjects and 20 patients with gastro‐oesophageal reflux disease. Data were expressed as medians and compared using Mann–Whitney and chi‐squared tests. Results Oesophageal motility disorders were similarly distributed between the groups. Multiphasic contractions occurred more frequently in patients with diabetes than in those with gastro‐oesophageal reflux disease (60 vs 20% per patient; P