Association between bone mineral density and type 1 diabetes mellitus: a meta-analysis of cross-sectional studies

Summary A few studies have investigated the relationship between type 1 diabetes mellitus (T1DM) and bone mineral density (BMD) values. This meta‐analysis was performed to explore differences between T1DM and healthy individuals in BMD values measured at five bone sites.We searched the database of PubMed for cross‐sectional studies about the association of T1DM and BMD, and a meta‐analysis was conducted.The results suggested significant association between T1DM and decreased BMD values of total body. The pooled mean differences (MDs) were −0.06 [95% confidence interval (CI): −0.11, −0.01] for all people. As for the association between T1DM and spine BMD values, the pooled MDs were −0.04 (95% CI: −0.07, −0.01) for males and −0.03 (95% CI: −0.06, 0.00) for females