Vitamin B12 deficiency
Vitamin B^sub 12^ is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences. Intracellular conversion of vitamin B^sub 1...
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Veröffentlicht in: | BMJ (Online) 2014-09, Vol.349 (7973), p.g5226-g5226 |
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Sprache: | eng |
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Zusammenfassung: | Vitamin B^sub 12^ is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences. Intracellular conversion of vitamin B^sub 12^ to two active coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the homeostasis of methylmalonic acid and homocysteine, respectively. Methylmalonic acid is converted into succinyl-CoA, of which vitamin B^sub 12^ is a cofactor for the reaction. Homocysteine is biosynthesized from rnethionine then resynthesized into methionine or converted into amino acid cysteine. Vitamin B^sub 12^ deficiency is relatively common, with important and variable clinical consequences. Here, Hunt et al present a concise summary of the most up to date evidence on how to diagnose and manage vitamin B^sub 12^ deficiency. |
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ISSN: | 0959-8138 1756-1833 0959-8146 1756-1833 |
DOI: | 10.1136/bmj.g5226 |