Vitamin B12 deficiency

Vitamin B^sub 12^ is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences. Intracellular conversion of vitamin B^sub 1...

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Veröffentlicht in:BMJ (Online) 2014-09, Vol.349 (7973), p.g5226-g5226
Hauptverfasser: Hunt, Alesia, Harrington, Dominic, Robinson, Susan
Format: Artikel
Sprache:eng
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Zusammenfassung:Vitamin B^sub 12^ is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences. Intracellular conversion of vitamin B^sub 12^ to two active coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the homeostasis of methylmalonic acid and homocysteine, respectively. Methylmalonic acid is converted into succinyl-CoA, of which vitamin B^sub 12^ is a cofactor for the reaction. Homocysteine is biosynthesized from rnethionine then resynthesized into methionine or converted into amino acid cysteine. Vitamin B^sub 12^ deficiency is relatively common, with important and variable clinical consequences. Here, Hunt et al present a concise summary of the most up to date evidence on how to diagnose and manage vitamin B^sub 12^ deficiency.
ISSN:0959-8138
1756-1833
0959-8146
1756-1833
DOI:10.1136/bmj.g5226